Preclinical characterization of 5-amino-4-oxo-[6-11C] hexanoic acid as an imaging probe to estimate protoporphyrin IX accumulation induced by exogenous …
C Suzuki, AB Tsuji, K Kato, T Kikuchi… - Journal of Nuclear …, 2014 - Soc Nuclear Med
Preoperative noninvasive imaging to estimate the quantity and spatial distribution of
protoporphyrin IX (PpIX) accumulation in tumors induced by 5-aminolevulinic acid (ALA) …
protoporphyrin IX (PpIX) accumulation in tumors induced by 5-aminolevulinic acid (ALA) …
Synthesis and in vitro cellular uptake of 11C-labeled 5-aminolevulinic acid derivative to estimate the induced cellular accumulation of protoporphyrin IX
Protoporphyrin IX (PpIX) accumulation induced by exogenous 5-aminolevulinic acid (ALA)
in tumors affects the therapeutic efficacy of ALA-based photodynamic and sonodynamic …
in tumors affects the therapeutic efficacy of ALA-based photodynamic and sonodynamic …
Fluorescence-based measurement of real-time kinetics of protoporphyrin IX after 5-aminolevulinic acid administration in human in situ malignant gliomas
S Kaneko, ES Molina, C Ewelt, N Warneke… - …, 2019 - journals.lww.com
BACKGROUND Five-aminolevulinic acid (5-ALA) is well established for fluorescence-
guided resections of malignant gliomas by eliciting the accumulation of fluorescent …
guided resections of malignant gliomas by eliciting the accumulation of fluorescent …
[HTML][HTML] 5-aminolevulinic acid-induced protoporphyrin IX fluorescence imaging for tumor detection: Recent advances and challenges
Y Harada, Y Murayama, T Takamatsu, E Otsuji… - International journal of …, 2022 - mdpi.com
5-Aminolevulinic acid (5-ALA) is a natural amino acid and a precursor of heme and
chlorophyll. Exogenously administered 5-ALA is metabolized into protoporphyrin IX (PpIX) …
chlorophyll. Exogenously administered 5-ALA is metabolized into protoporphyrin IX (PpIX) …
5‐Aminolevulinic acid‐induced protoporphyrin IX levels in tissue of human malignant brain tumors
A Johansson, G Palte, O Schnell… - Photochemistry and …, 2010 - Wiley Online Library
Protoporphyrin IX (PpIX) produced from exogenous, orally administered 5‐aminolevulinic
acid (ALA) displays high tumor‐selective uptake and is being successfully employed for …
acid (ALA) displays high tumor‐selective uptake and is being successfully employed for …
Methods to measure the inhibition of ABCG2 transporter and ferrochelatase activity to enhance aminolevulinic acid-protoporphyrin IX fluorescence-guided tumor …
M Mansi, R Howley, B Chen - Biomedical Engineering Technologies …, 2022 - Springer
Aminolevulinic acid (ALA) has been clinically used as an intraoperative fluorescence probe
for protoporphyrin IX (PpIX) fluorescence-guided tumor resection and a PDT agent for …
for protoporphyrin IX (PpIX) fluorescence-guided tumor resection and a PDT agent for …
[HTML][HTML] 5-Aminolevulinic Acid as a Theranostic Agent for Tumor Fluorescence Imaging and Photodynamic Therapy
R Howley, S Chandratre, B Chen - Bioengineering, 2023 - mdpi.com
5-Aminolevulinic acid (ALA) is a naturally occurring amino acid synthesized in all nucleated
mammalian cells. As a porphyrin precursor, ALA is metabolized in the heme biosynthetic …
mammalian cells. As a porphyrin precursor, ALA is metabolized in the heme biosynthetic …
[HTML][HTML] Characterization of plasma-derived protoporphyrin-IX-positive extracellular vesicles following 5-ALA use in patients with malignant glioma
PS Jones, A Yekula, E Lansbury, JL Small, C Ayinon… - …, 2019 - thelancet.com
Background Malignant gliomas are rapidly progressive brain tumors with high mortality.
Fluorescence guided surgery (FGS) with 5-aminolevulinic acid (5-ALA) provides fluorescent …
Fluorescence guided surgery (FGS) with 5-aminolevulinic acid (5-ALA) provides fluorescent …
[HTML][HTML] Evaluation of aminolevulinic acid-mediated protoporphyrin IX fluorescence and enhancement by ABCG2 inhibitors in renal cell carcinoma cells
R Howley, M Mansi, J Shinde, J Restrepo… - Journal of Photochemistry …, 2020 - Elsevier
Aminolevulinic acid (ALA) has been approved as an intraoperative molecular imaging probe
for protoporphyrin IX (PpIX) fluorescence-guided resection of glioma. Here we explored its …
for protoporphyrin IX (PpIX) fluorescence-guided resection of glioma. Here we explored its …
Localization of protoporphyrin IX in glioma patients with paired stimulated Raman histology and two-photon excitation fluorescence microscopy
Fluorescence guidance is widely utilized to improve the precision of cancer surgery. 5-
aminolevulinic acid, the most widely used fluorophore in glioma surgery, is thought to cause …
aminolevulinic acid, the most widely used fluorophore in glioma surgery, is thought to cause …