Herpes simplex virus type 1 thymidine kinase (HSV1-TK) is a widely used reporter for in vivo
noninvasive monitoring of therapeutic gene expression, immune cell trafficking, and protein …

The herpes simplex virus type 1 thymidine kinase (HSV1-TK) reporter system is being used
to directly and indirectly monitor therapeutic gene expression, immune cell trafficking and …

Purpose The aim of this study was to create an alternative mutant of the herpes simplex virus
type 1 thymidine kinase (HSV1-tk) reporter gene with reduced phosphorylation capacity for …

Imaging 2 different molecular–genetic events in a single subject by PET is essential in a
variety of in vivo applications. Using herpes simplex virus-1 thymidine kinase (HSV1-tk) …

Purpose To assess the optimal reporter probe/reporter gene combination for monitoring
herpes simplex virus type 1 thymidine kinase (HSV1-tk) gene expression, we compared the …

Objective The herpes simplex virus thymidine kinase (HSVtk) gene has frequently been
applied as a reporter gene for monitoring transgene expression in animal models. In clinical …

To develop efficient and safe gene therapy approaches, the herpes simplex virus type 1
thymidine kinase gene (HSV-1-tk) has been shown to function as a marker gene for the …

The herpes simplex virus type 1 thymidine kinase (HSV1-tk) gene is widely used as a
suicide gene in combination with ganciclovir (GCV) and as a nuclear imaging reporter gene …

Imaging transgene expression with radiopharmaceuticals is feasible and has been
demonstrated with a gamma camera and by positron emission tomography (PET) in …

INTRODUCTION: Imaging of gene expression with positron emission tomography (PET) has
emerged as a powerful tool for biomedical research during the last decade. The prototypical …