Predictive value of early-stage uptake of 3′-deoxy-3′-18F-fluorothymidine in cancer cells treated with charged particle irradiation

C Lin, K Kume, T Mori, ME Martinez… - Journal of Nuclear …, 2015 - Soc Nuclear Med
The aim of this study was to investigate whether 3′-deoxy-3′-18F-fluorothymidine (18F-
FLT) can monitor the early response of tumor cell proliferation to charged particle irradiation …

Evaluation of 3′-deoxy-3′-18F-fluorothymidine for monitoring tumor response to radiotherapy and photodynamic therapy in mice

M Sugiyama, H Sakahara, K Sato… - Journal of Nuclear …, 2004 - Soc Nuclear Med
3′-Deoxy-3′-18F-fluorothymidine (18F-FLT) has been suggested as a new PET tracer for
imaging tumor proliferation. We investigated the use of 18F-FLT to monitor the response of …

Thymidine Metabolism as a Confounding Factor for 3′-Deoxy-3′-18F-Fluorothymidine Uptake After Therapy in a Colorectal Cancer Model

S Schelhaas, L Wachsmuth, S Hermann… - Journal of Nuclear …, 2018 - Soc Nuclear Med
Noninvasive monitoring of tumor therapy response helps in developing personalized
treatment strategies. Here, we performed sequential PET and diffusion-weighted MRI to …

18F-Fluorothymidine radiation dosimetry in human PET imaging studies

H Vesselle, J Grierson, LM Peterson… - Journal of Nuclear …, 2003 - Soc Nuclear Med
3′-Deoxy-3′-18F-fluorothymidine (18F-FLT) is a PET imaging agent that shows promise
for studying cellular proliferation in human cancers. FLT is a nucleoside analog that enters …

Use of 3′-deoxy-3′-[18F]fluorothymidine PET to monitor early responses to radiation therapy in murine SCCVII tumors

YJ Yang, JS Ryu, SY Kim, SJ Oh, KC Im, H Lee… - European journal of …, 2006 - Springer
Abstract Purpose 3′-Deoxy-3′-[18 F] fluorothymidine (FLT) is a promising new
radiopharmaceutical for imaging cell proliferation. We evaluated whether FLT PET can be …

Single-cell characterization of 18F-FLT uptake with radioluminescence microscopy

D Sengupta, G Pratx - Journal of Nuclear Medicine, 2016 - Soc Nuclear Med
The radiotracer 3′-deoxy-3′-18F-fluorothymidine (18F-FLT) is commonly used to measure
cell proliferation in vivo. As a marker of cell proliferation, 18F-FLT is expected to be …

Monitoring the early biologic response of esophageal carcinoma after irradiation with 18F-FLT: an in-vitro and in-vivo study

M Jiang, Q Huang, P Chen, X Ruan, Z Luo… - Nuclear Medicine …, 2014 - journals.lww.com
Objective The aim of our study was to explore the value of 3′-deoxy-3′-[18 F]
fluorothymidine (18 F-FLT) and 18 F-FLT PET in monitoring the early biologic response of …

3′-Deoxy-3′-[18F]Fluorothymidine Uptake Is Related to Thymidine Phosphorylase Expression in Various Experimental Tumor Models

S Schelhaas, K Heinzmann, DJ Honess… - Molecular Imaging and …, 2018 - Springer
Purpose We recently reported that high thymidine phosphorylase (TP) expression is
accompanied by low tumor thymidine concentration and high 3′-deoxy-3′-[18 F] …

Dynamic small-animal PET imaging of tumor proliferation with 3′-deoxy-3′-18F-fluorothymidine in a genetically engineered mouse model of high-grade gliomas

MS Bradbury, D Hambardzumyan… - Journal of Nuclear …, 2008 - Soc Nuclear Med
3′-Deoxy-3′-18F-fluorothymidine (18F-FLT), a partially metabolized thymidine analog,
has been used in preclinical and clinical settings for the diagnostic evaluation and …

[HTML][HTML] Toxicology evaluation of radiotracer doses of 3'-deoxy-3'-[18F]fluorothymidine (18F-FLT) for human PET imaging: Laboratory analysis of serial blood …

E Turcotte, LW Wiens, JR Grierson, LM Peterson… - BMC nuclear …, 2007 - Springer
Background 18 F-FLT is a novel PET radiotracer which has demonstrated a strong potential
utility for imaging cellular proliferation in human tumors in vivo. To facilitate future regulatory …