All patients were treated in single rooms with appropriate shielding to minimize exposure of
health care personnel. The †53Sm-EDTMPwas infused over 30 min by an infusion pump …

METhOD Patient Selection Five patients with histopathologically proven primary can cer and
radiographic and/or scintigraphic bony metastases werestudiedunderphysiciansIND27865 …

Background Bone metastases are responsible for most of the morbidity associated with
hormone-refractory prostate cancer (HRPC). 153 Sm-ethylenediaminetetramethylene …

I452 The Journalof NuclearMedicine• Vol. 33 • No. 8 • August1992 more of the
following: x-ray,@ mTc@ HDPbone image, Cl'scan, MRI and bone biopsy. The study was …

Rhenium-188 dimercaptosuccinic acid complex [188 Re (V) DMSA], a potential therapeutic
analogue of the tumour imaging agent 99m Tc (V) DMSA, is selectively taken up in bone …

Rhenium-186 (tin) hydroxyethylidene diphosphonate (HEDP) is a new radiopharmaceutical
that localizes in areas of osseous metastases in a manner similar to that of standard bone …

Various radioisotopes conjugated to pyrophosphate analogues have been developed for
systemic metabolic radiotherapy. Samarium-153-EDTMP is a 1: 1 complex of radioactive …

Metastatic disease to bone is commonly seen in the advanced stages of many cancers. The
cardinal symptom, pain, is often the cause of significant morbidity and reduced quality of life …

Results Complete pain relief was found in 40% of women and 40% of men treated using 153
Sm-EDTMP and in 25% of women and 33% of men treated with 89 Sr. No analgesic effect …

Abstract 153 Sm-EDTMP (ethylenediaminetetramethylene phosphonate), prepared from a
kit, was administered to 28 patients in a clinical trial of therapy for painful skeletal …