A PET brain reporter gene system based on type 2 cannabinoid receptors
C Vandeputte, N Evens, J Toelen… - Journal of Nuclear …, 2011 - Soc Nuclear Med
PET of gene expression in the brain may greatly facilitate neuroscience research and
potential clinical implementation of gene or cell therapy of central nervous system diseases …
potential clinical implementation of gene or cell therapy of central nervous system diseases …
Preclinical evaluation of [18F]MA3: a CB2 receptor agonist radiotracer for PET
B Attili, S Celen, M Ahamed, M Koole… - British Journal of …, 2019 - Wiley Online Library
Background and Purpose Non‐invasive in vivo imaging of cannabinoid CB2 receptors using
PET is pursued to study neuroinflammation. The purpose of this study is to evaluate the in …
PET is pursued to study neuroinflammation. The purpose of this study is to evaluate the in …
Preclinical evaluation of [11C] NE40, a type 2 cannabinoid receptor PET tracer
N Evens, C Vandeputte, C Coolen, P Janssen… - Nuclear medicine and …, 2012 - Elsevier
INTRODUCTION: Up-regulation of the type 2 cannabinoid receptor (CB2R) has been
reported in (neuro) inflammatory diseases. In this study, we report the preclinical evaluation …
reported in (neuro) inflammatory diseases. In this study, we report the preclinical evaluation …
11C-JHU75528: a radiotracer for PET imaging of CB1 cannabinoid receptors
AG Horti, H Fan, H Kuwabara, J Hilton… - Journal of Nuclear …, 2006 - Soc Nuclear Med
The development of the radioligands for PET imaging of the cerebral cannabinoid receptor
(CB1) is of great importance for studying its role in neuropsychiatric disorders, obesity, and …
(CB1) is of great importance for studying its role in neuropsychiatric disorders, obesity, and …
Quantification of 11C-NE40, a novel PET radioligand for CB2 receptor imaging
A Postnov, R Ahmad, N Evens, J Versijpt… - 2013 - Soc Nuclear Med
188 Objectives The type 2 cannabinoid receptor (CB2R) is part of the endocannabinoid
system and is expressed in tissues related to the immune system. CB2R upregulation has …
system and is expressed in tissues related to the immune system. CB2R upregulation has …
PET imaging of cannabinoid type 2 receptors with [11C]A-836339 did not evidence changes following neuroinflammation in rats
G Pottier, V Gómez-Vallejo, D Padro… - Journal of Cerebral …, 2017 - journals.sagepub.com
Cannabinoid type 2 receptors (CB2R) have emerged as promising targets for the diagnosis
and therapy of brain pathologies. However, no suitable radiotracers for accurate CB2R …
and therapy of brain pathologies. However, no suitable radiotracers for accurate CB2R …
Imaging and quantitation of cannabinoid CB1 receptors in human and monkey brains using 18F-labeled inverse agonist radioligands
GE Terry, J Hirvonen, JS Liow, SS Zoghbi… - Journal of Nuclear …, 2010 - Soc Nuclear Med
We recently demonstrated that 11C-MePPEP, a PET ligand for CB1 receptors, has such high
uptake in the human brain that it can be imaged for 210 min and that receptor density can be …
uptake in the human brain that it can be imaged for 210 min and that receptor density can be …
In vitro and in vivo evaluation of 11C-SD5024, a novel PET radioligand for human brain imaging of cannabinoid CB1 receptors
T Tsujikawa, SS Zoghbi, J Hong, SR Donohue… - Neuroimage, 2014 - Elsevier
We recently developed a novel cannabinoid subtype-1 (CB 1) receptor radioligand 11 C-
SD5024 for brain imaging. This study aimed to evaluate 11 C-SD5024 both in vitro and in …
SD5024 for brain imaging. This study aimed to evaluate 11 C-SD5024 both in vitro and in …
Development of radioligands for in vivo imaging of type 1 cannabinoid receptors (CB1) in human brain
Cerebral cannabinoid receptor (CB1) and cannabinoid drugs constitute a vibrant field in
modern medicine and pharmacology. However, the physiological and pharmacological …
modern medicine and pharmacology. However, the physiological and pharmacological …
PET Imaging Studies in Rhesus Monkey with the Cannabinoid-1 (CB1) Receptor Ligand [11C]CB-119
TG Hamill, LS Lin, W Hagmann, P Liu, J Jewell… - Molecular imaging and …, 2009 - Springer
Purpose The in vitro and in vivo evaluation of the selective, high affinity (human CB1 IC 50
0.49 nM) inverse agonist CB1R tracer [11 C] CB-119, a close analog of the previously …
0.49 nM) inverse agonist CB1R tracer [11 C] CB-119, a close analog of the previously …