PET imaging of tumor-associated macrophages with 89Zr-labeled high-density lipoprotein nanoparticles

C Pérez-Medina, J Tang, D Abdel-Atti… - Journal of nuclear …, 2015 - Soc Nuclear Med
Tumor-associated macrophages (TAMs) are increasingly investigated in cancer immunology
and are considered a promising target for better and tailored treatment of malignant growth …

A modular labeling strategy for in vivo PET and near-infrared fluorescence imaging of nanoparticle tumor targeting

C Pérez-Medina, D Abdel-Atti, Y Zhang… - Journal of Nuclear …, 2014 - Soc Nuclear Med
Advances in preclinical molecular imaging have generated new opportunities to
noninvasively visualize the biodistribution and tumor targeting of nanoparticle therapeutics …

Radiolabeling of lipid-based nanoparticles for diagnostics and therapeutic applications: a comparison using different radiometals

A Helbok, C Decristoforo, G Dobrozemsky… - Journal of liposome …, 2010 - Taylor & Francis
Radiolabeling of nanoparticles (NPs) has been performed for a variety of reasons, such as
for studying pharmacokinetics, for imaging, or for therapy. Here, we describe the in vitro and …

In vivo PET imaging of HDL in multiple atherosclerosis models

C Pérez-Medina, T Binderup, ME Lobatto… - JACC: Cardiovascular …, 2016 - jacc.org
Objectives: The goal of this study was to develop and validate a noninvasive imaging tool to
visualize the in vivo behavior of high-density lipoprotein (HDL) by using positron emission …

Therapeutic efficacy and microSPECT/CT imaging of 188Re-DXR-liposome in a C26 murine colon carcinoma solid tumor model

YJ Chang, CH Chang, CY Yu, TJ Chang… - Nuclear medicine and …, 2010 - Elsevier
Nanocarriers can selectively target cancer sites and carry payloads, thereby improving
diagnostic and therapeutic effectiveness and reducing toxicity. The objective of this study …

[HTML][HTML] The yin and yang of imaging tumor associated macrophages with PET and MRI

S Mukherjee, D Sonanini, A Maurer… - Theranostics, 2019 - ncbi.nlm.nih.gov
Tumor associated macrophages (TAM) are key players in the cancer microenvironment.
Molecular imaging modalities such as MRI and PET can be used to track and monitor TAM …

Tumor targeting and imaging with dual-peptide conjugated multifunctional liposomal nanoparticles

C Rangger, A Helbok, J Sosabowski… - International journal …, 2013 - Taylor & Francis
Background The significant progress in nanotechnology provides a wide spectrum of
nanosized material for various applications, including tumor targeting and molecular …

Novel Method to Label Solid Lipid Nanoparticles with 64Cu for Positron Emission Tomography Imaging

E Andreozzi, JW Seo, K Ferrara, A Louie - Bioconjugate chemistry, 2011 - ACS Publications
Solid lipid nanoparticles (SLNs) are submicrometer (1− 1000 nm) colloidal carriers
developed in the past decade as an alternative system to traditional carriers (emulsions …

[HTML][HTML] Companion diagnostic 64Cu-liposome positron emission tomography enables characterization of drug delivery to tumors and predicts response to cancer …

H Lee, D Gaddy, M Ventura, N Bernards… - Theranostics, 2018 - ncbi.nlm.nih.gov
Deposition of liposomal drugs into solid tumors is a potentially rate-limiting step for drug
delivery and has substantial variability that may influence probability of response. Tumor …

A generic 89Zr labeling method to quantify the in vivo pharmacokinetics of liposomal nanoparticles with positron emission tomography

N Li, Z Yu, TT Pham, PJ Blower… - International Journal of …, 2017 - Taylor & Francis
Liposomal nanoparticles are versatile drug delivery vehicles that show great promise in
cancer therapy. In an effort to quantitatively measure their in vivo pharmacokinetics, we …