Facile automated synthesis of [18F] fluoromethyl-d2 group in a commercial 18F-synthetic module

BM Jo, BS Moon, HJ Lee, HS Park, BC Lee, SE Kim - 2015 - Soc Nuclear Med
2503 Objectives In our recent study, we demonstrated that 18 F-fluoromethyl ether group
could be used the convenient application for radiofluorination of 11 C-radiotracer containing …

[HTML][HTML] Optimization of 18F-syntheses using 19F-reagents at tracer-level concentrations and LC-MS/MS analysis: improved synthesis of [18F] MDL100907

X Zhang, R Dunlow, BN Blackman… - Journal of labelled …, 2018 - ncbi.nlm.nih.gov
Traditional radiosynthetic optimization faces the challenges of high radiation exposure, cost
and inability to perform serial reactions due to tracer decay. To accelerate tracer …

Research on multifunctional 18F synthesis module with two vessels

Z Jin-ming, Z Xiao-jun, LI Yun-gang… - Chinese Journal of …, 2010 - pesquisa.bvsalud.org
Objective To explore a new 18F multifunctional synthesis module with two vessels to
synthesize various kinds of 18F labeled radiopharmaceuticals for clinical utilities. Methods …

A simple and rapid automated radiosynthesis of [18F]fluoroacetate

G Tang, X Tang, M Wang, B Li… - Journal of Labelled …, 2008 - Wiley Online Library
Two fully automated synthetic procedures of [18F] fluoroacetate ([18F] FAC) have been
developed using a modified commercial TRACERlab FXFN synthesizer. One was a two …

Optimization of 18F‐syntheses using 19F‐reagents at tracer‐level concentrations and liquid chromatography/tandem mass spectrometry analysis: Improved synthesis …

X Zhang, R Dunlow, BN Blackman… - Journal of Labelled …, 2018 - Wiley Online Library
Traditional radiosynthetic optimization faces the challenges of high radiation exposure, cost,
and inability to perform serial reactions due to tracer decay. To accelerate tracer …

Practical Synthesis of 18F-Difluoromethylarenes from Aryl Halides

S Liang, H Shi, R Tobias, N Vasdev - 2016 - Soc Nuclear Med
326 Objectives Development of modern 18 F-multi-fluoromethylation reactions are actively
pursued as CF 2 and CF 3 groups are prevalent in drug development but have remained …

Efficient automated syntheses of high specific activity 6‐[18F]fluorodopamine using a diaryliodonium salt precursor

KD Neumann, L Qin, AL Vāvere, B Shen… - Journal of Labelled …, 2016 - Wiley Online Library
6‐[18F] Fluorodopamine (6‐[18F] F‐DA) is a positron emission tomography
radiopharmaceutical used to image sympathetic cardiac innervation and neuroendocrine …

A simple method to generate [18F] triflyl fluoride for 18F radiosynthesis

D Zhou, JA Katzenellenbogen - Tetrahedron Letters, 2021 - Elsevier
A simple, continuous-flow solid-phase radiosynthesis method has been developed for the
generation of [18 F] triflyl fluoride as a source of [18 F] fluoride for the preparation of 18 F …

Automated synthesis of 18F-fluoroacetate as tumor imaging agent

G Tang, M Wang, L Luo, M Gan, X Tang - Nuclear Techniques, 2006 - inis.iaea.org
[en] To improve the automated synthesis technology of 18 F-fluoroacetate (18 F-FAC) as
tumor imaging agent, the one-pot procedure at TRACERlab FX FN module was tried. 18 F …

Automated radiosynthesis of no‐carrier‐added 4‐[18F]fluoroiodobenzene: a versatile building block in 18F radiochemistry

JD Way, F Wuest - Journal of Labelled Compounds and …, 2014 - Wiley Online Library
4‐[18F] Fluoroiodobenzene ([18F] FIB) is a versatile building block in 18F radiochemistry
used in various transition metal‐mediated C–C and C–N cross‐coupling reactions and [18F] …