Changes in gene expression, metabolism, and energy requirements are hallmarks of cancer
growth and self-sufficiency. Upregulation of the PI3K/Akt/mTor pathway in tumor cells has …

Glucose and glutamine are the most abundant nutrients for producing energy and building
blocks in normal and tumor cells. Increased glycolysis in tumors, the Warburg Effect, is the …

Glucose and glutamine are the two principal nutrients that cancer cells use to proliferate and
survive. Many cancers show altered glucose metabolism, which constitutes the basis for in …

Recently, there has been a renewed interest in the study of tumor metabolism above and
beyond the Warburg effect. Studies on cancer cell metabolism have provided evidence that …

Purpose To assess the clinical safety, pharmacokinetics, and tumor imaging characteristics
of fluorine 18–(2S, 4R)-4-fluoroglutamine (FGln), a glutamine analog radiologic imaging …

18F-labeled (2 S, 4 R)-4-fluoro-l-glutamine (4F-GLN) has demonstrated high uptake in tumor
cells that undergo high growth and proliferation. Similar tumor targeting properties have also …

Metabolic imaging has great clinical potential in cancer because perturbations of
metabolism are common hallmarks of malignant cellular transformation. Novel imaging …

Although the growth and proliferation of most tumors is fueled by glucose, some tumors are
more likely to metabolize glutamine. In particular, tumor cells with the upregulated c-Myc …

There is a high demand for tumor specific PET tracers in oncology imaging. Besides
glucose, certain amino acids also serve as energy sources and anabolic precursors for …

FDG PET imaging has been applied for about a decade. It is generally accepted that
imaging the metabolic activity of tumor tissue provides more sensitive and more specific …