Aptamers are small oligonucleotides that are selected to bind tightly and specifically to a
target molecule. We sought to determine whether aptamers have potential for in vivo …

Tenascin-C (TN-C) is an extracellular matrix protein that is overexpressed during tissue
remodeling processes, including tumor growth. To identify an aptamer for testing as a tumor …

Introduction aptamers are short artificial, single-strand oligonucleotide sequences (DNA,
RNA or modified RNA), capable of binding to biological molecules with high affinity and …

Aptamers are short oligonucleotides that bind to specific target molecules. They have been
extensively explored in biomedical applications, including biosensing, medical imaging, and …

Aptamers represent a potentially important class of ligands for the development of
diagnostics and therapeutics. However, it is often difficult to compare the function and …

Aptamers, single-stranded oligonucleotides, are an important class of molecular targeting
ligand. Since their discovery, aptamers have been rapidly translated into clinical practice …

Insufficient penetration of therapeutic agents into tumor tissues results in inadequate drug
distribution and lower intracellular concentration of drugs, leading to the increase of drug …

Aptamers are single-stranded DNA or RNA oligonucleotides that assume specific 3D
structures and bind to target molecules with high affinity. The unique specificity of aptamers …

The development of an aptamer-based therapeutic has rapidly progressed following the first
two reports in the 1990s, underscoring the advantages of aptamer drugs associated with …

Aptamers are single-stranded oligonucleotides with high affinity and specificity to the target
molecules or cells, thus they can serve as an important category of molecular targeting …