Microfluidic preparation of a 89Zr-labeled trastuzumab single-patient dose
89Zr-labeled antibodies are being investigated in several clinical trials; however, the time
requirement for synthesis of clinical doses can hinder patient throughput because of …
requirement for synthesis of clinical doses can hinder patient throughput because of …
Biodistribution of 212Pb conjugated trastuzumab in mice
NR Schneider, M Lobaugh, Z Tan, P Sandwall… - … of Radioanalytical and …, 2013 - Springer
The biodistribution in mice of 212 Pb-trastuzumab, a HER2 targeting immunoglobulin
(monoclonal antibody), was investigated for its potential as a therapeutic agent with …
(monoclonal antibody), was investigated for its potential as a therapeutic agent with …
89Zr for antibody labeling and in vivo studies–a comparison between liquid and solid target production
GM Dias, CF Ramogida, J Rousseau… - Nuclear medicine and …, 2018 - Elsevier
Abstract Introduction Zirconium-89 (89 Zr, t 1/2= 78.4 h) liquid target (LT) production offers
an approach to introduce this positron-emitting isotope to cyclotron centres without the need …
an approach to introduce this positron-emitting isotope to cyclotron centres without the need …
[HTML][HTML] Comparative pharmacokinetics of trastuzumab subcutaneous formulation administered using a proprietary single-use injection device, or manually using a …
C Wynne, DS Waaka, RB Ellis-Pegler, C Schwabe… - Annals of …, 2012 - Elsevier
Background Intravenous (IV) trastuzumab, alone or with chemotherapy, is the standard of
care for HER2-positive breast cancer and metastatic gastric cancer. The subcutaneous (SC) …
care for HER2-positive breast cancer and metastatic gastric cancer. The subcutaneous (SC) …
Targeting HER2: a report on the in vitro and in vivo pre-clinical data supporting trastuzumab as a radioimmunoconjugate for clinical trials
DE Milenic, KJ Wong, KE Baidoo, TK Nayak… - MAbs, 2010 - Taylor & Francis
The potential of the HER2-targeting antibody trastuzumab as a radioimmunoconjugate
useful for both imaging and therapy was investigated. Conjugation of trastuzumab with the …
useful for both imaging and therapy was investigated. Conjugation of trastuzumab with the …
Development and validation of an enzyme-linked immunosorbent assay for the quantification of trastuzumab in human serum and plasma
CWN Damen, ER de Groot, M Heij, DS Boss… - Analytical …, 2009 - Elsevier
Trastuzumab, a humanized monoclonal antibody, is used for the treatment of breast cancer
patients who overexpress the HER2 receptor. To optimize therapy, pharmacokinetic studies …
patients who overexpress the HER2 receptor. To optimize therapy, pharmacokinetic studies …
The pharmaceutical stability of trastuzumab after short-term storage at room temperature assessed by analytical techniques and tumour imaging by microSPECT/CT
C Chan, JT Seki, R Kwong, RM Reilly - International Journal of …, 2020 - Elsevier
We report the pharmaceutical stability of trastuzumab stored for a short time (12 h) at room
temperature (RT; 20–25° C) compared to trastuzumab stored at 2–8° C. The …
temperature (RT; 20–25° C) compared to trastuzumab stored at 2–8° C. The …
[PDF][PDF] Preparation of F (ab') 2 trastuzumab fragment for Radioimmunoconjugate synthesis of 177 Lu-DOTA-F (ab') 2-trastuzumab
S Hermanto, RD Haryuni, M Ramli… - IOSR Journal of …, 2012 - researchgate.net
Radioimmunodiagnosis or radioimmunotherapy is a technique that has been developed
and used in cancer management in recent years. The use of this technique which is based …
and used in cancer management in recent years. The use of this technique which is based …
Direct 99mTc labeling of Herceptin (trastuzumab) by 99mTc (I) tricarbonyl ion
WJ Chen, CL Yen, ST Lo, KT Chen, JM Lo - Applied Radiation and …, 2008 - Elsevier
By simply incubating Herceptin (trastuzumab) with [99mTc (CO) 3 (OH2) 3]+ ion in saline, a
significant yield of 99mTc-labeled trastuzumab was found to be achievable. The effective …
significant yield of 99mTc-labeled trastuzumab was found to be achievable. The effective …
[HTML][HTML] Automated light-induced synthesis of 89Zr-radiolabeled antibodies for immuno-positron emission tomography
S Klingler, JP Holland - Scientific reports, 2022 - nature.com
Clinical production of 89Zr-radiolabeled antibodies (89Zr-mAbs) for positron emission
tomography imaging relies on the pre-conjugation of desferrioxamine B (DFO) to the purified …
tomography imaging relies on the pre-conjugation of desferrioxamine B (DFO) to the purified …