Heterogeneity in metastatic breast cancer 18F-fluoroestradiol uptake: clinically actionable, biologically illuminating?

BF Kurland, S Oesterreich - Journal of Nuclear Medicine, 2018 - Soc Nuclear Med
Metastatic breast cancer from an estrogen receptor (ER)–positive primary tumor is rarely
cured, but patients often live for many years with their disease (1). A wide range of therapy …

18F-fluoroestradiol tumor uptake is heterogeneous and influenced by site of metastasis in breast cancer patients

HH Nienhuis, M van Kruchten, SG Elias… - Journal of Nuclear …, 2018 - Soc Nuclear Med
Heterogeneity of estrogen receptor (ER) expression in breast cancer is recognized.
However, knowledge about varying expression across metastases and surrounding normal …

The uses of 18F-fluoroestradial (FES) PET with and without 18F-fluorodeoxyglucose (FDG) PET in breast cancer evaluation

L Peterson, B Kurland, P Romine, J Lee, A Novakova… - 2017 - Soc Nuclear Med
955 Objectives: 18 F-Fluoroestradiol (FES) is an estrogen analogue that has been shown to
be a promising ER imaging agent in breast cancer. FES uptake correlates with tumor ER …

Early results of an NCI-sponsored Phase II study of 18F-fluoroestradiol (FES) PET imaging of metastatic breast cancer (MBC)

L Peterson, B Kurland, H Linden, J Link, E Schubert… - 2012 - Soc Nuclear Med
329 Objectives FES PET imaging reflects estrogen receptor (ER) density in breast cancer
tumors. Identifying low or absent ER expression through PET imaging may help to select …

NCI-sponsored phase II study of [18f]fluoroestradiol (FES) as a marker of hormone sensitivity of metastatic breast cancer: Initial results.

DA Mankoff, HM Linden, J Link, BF Kurland… - Journal of Clinical …, 2011 - ascopubs.org
e11104 Background: Molecular imaging of regional ER expression in breast cancer by FES
PET has been shown to indentify patients with low or absent uptake who are unlikely to …

18F-Fluoroestradiol PET to predict the response to neoadjuvant treatment of luminal breast cancer

D Groheux - Journal of Nuclear Medicine, 2017 - Soc Nuclear Med
TO THE EDITOR: Chae et al.(1) prospectively investigated the ability of pretreatment 18F-
fluoroestradiol PET/CT to predict the pathologic response to neoadjuvant therapy in …

Can fluorine-18 fluoroestradiol positron emission tomography–computed tomography demonstrate the heterogeneity of breast cancer in vivo?

Z Yang, Y Sun, Y Zhang, J Xue, M Wang, W Shi… - Clinical breast …, 2013 - Elsevier
Aim Our study was to investigate the heterogeneity of estrogen receptor (ER) expression
among tumor sites by using fluorine-18 (18 F) fluoroestradiol (FES) positron-emission …

[PDF][PDF] Positron tomographic assessment of 16α-[18F] fluoro-17β-estradiol uptake in metastatic breast carcinoma

AH McGuire, F Dehdashti, BA Siegel… - Journal of Nuclear …, 1991 - Soc Nuclear Med
MATERIALS AND METHODS The study population consisted of 16 non-pregnant women
(mean age 58.7 yr; range 45-83 yr) with radiographic or clinical evidence of recurrent or …

Diagnostic accuracy and safety of 16α-[18F] fluoro-17β-estradiol positron emission tomography/computed tomography for the assessment of estrogen receptor status …

SY Chae, SH Ahn, SB Kim, BH Son, JW Lee, BS Ko… - 2018 - Soc Nuclear Med
487 Objectives: The standard diagnostic workup for recurrent or metastatic breast cancer
includes biopsy and determination of tumor estrogen receptor (ER) status. However, biopsy …

18F-Fluoroestradiol Whole-Body Imaging

BJ Grabher - Journal of Nuclear Medicine Technology, 2023 - Soc Nuclear Med
Treating and managing metastatic breast cancer can be challenging for breast oncologists
and their patients. Estrogen receptors (ERs) in a patient's primary tumor can be either …