The aim of the present study was to explore the applicability of an extracerebral reference
region for the quantification of cerebral receptors with PET. Methods: Male squirrel monkeys …

The PET radioligand 2-fluoro-3-[2-((S)-3-pyrrolinyl) methoxy] pyridine (18F-nifene) is an
α4β2* nicotinic acetylcholine receptor (nAChR) agonist developed to provide accelerated in …

2-18F-Fluoro-3-[2 (S)-2-azetidinylmethoxy] pyridine (2-18F-fluoro-A-85380) is a PET
radioligand that is specific for nicotinic acetylcholine receptors (nAChRs) and has a high …

We evaluated (−)-2-(6-[18F] fluoro-2, 3′-bipyridin-5′-yl)-7-methyl-7-aza-bicyclo [2.2. 1]
heptane (18F-AZAN), a novel radiotracer that binds to α4β2 nicotinic acetylcholine receptors …

Purpose Positron emission tomography (PET) radioligands specific to α 7 nicotinic
acetylcholine receptors (nAChRs) afford in vivo imaging of this receptor for …

There are only 2 currently available radioligands, 2-18F-FA and 6-18F-FA, for quantitative
PET of the main cerebral subtype of nicotinic acetylcholine receptors (α4β2-nAChRs) in …

Quantitative analysis of most positron emission tomography (PET) data requires arterial
blood sampling and dynamic scanning when the radioligand is administered as a bolus …

INTRODUCTION: Neuronal nicotinic acetylcholine receptors (nAChRs), widely distributed in
the human brain, are implicated in various neurophysiological processes as well as being …

The purpose of this study was to assess the utility of a new single-photon emission
tomography ligand,[123 I] 5-iodo-3-[2 (S)-2-azetidinylmethoxy] pyridine (5-IA-85380), to …

Purpose Currently available positron-emitting radiotracers for imaging of the α4β2 subtype
of nicotinic acetylcholine receptors (nAChRs) exhibit high and moderate specific binding in …