Tremendous efforts are currently dedicated to the development of novel therapies targeting
the androgen receptor (AR), the major driver of prostate cancer disease and its progression …

Sex hormone–binding globulin (SHBG) is believed to play a key role in steroidal
radiopharmaceutical delivery to target tissues in humans. To better understand the action of …

Although prostate cancer growth is regulated by androgens through the androgen receptor
(AR), in vitro assays of AR levels in prostate tumors have limited prognostic value. This might …

16β-18F-fluoro-5α-dihydrotestosterone (18F-FDHT) is a radiopharmaceutical that has been
investigated as a diagnostic agent for the assessment of androgen receptor (AR) density in …

Introduction Steroid hormones like androgens play an important role in the development and
maintenance of several brain functions. Androgens can act through androgen receptors …

The aim of this study was to develop a clinically applicable noninvasive method to quantify
changes in androgen receptor (AR) levels based on 18F-16β-fluoro-5α-dihydrotestosterone …

Purpose For this study, we have assessed the in vivo distribution and androgen receptor
(AR) seeking properties of an F-18-labeled androgen [18 F] FMDHT in rats castrated with a …

4 THE QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
March 2015 or even in meningiomas, may have therapeutic consequences and FES PET …

This trial was an initial assessment of the feasibility, in vivo targeting, and biokinetics of 16β-
18F-fluoro-5α-dihydrotestosterone (18F-FDHT) PET in patients with metastatic prostate …

The aim of this systematic review is to provide a comprehensive overview of the role of fluoro-
5α-dihydrotestosterone ([18F]-FDHT) for the in vivo imaging of androgen receptors (AR) …