The need to study dynamic biologic processes in intact small-animal models of disease has
stimulated the development of high-resolution nuclear imaging methods. These methods are …

Molecular imaging of small animals in vivo is vital in the study of mouse and rat models of
human diseases, and will provide important clues to the pathogenesis, progression and …

Molecular medicine enhances the clinician's ability to accurately diagnose and treat
disease, and many technological advances in diverse fields have made the translation of …

Molecular imaging refers to the use of non-invasive imaging techniques to detect signals
that originate from molecules, often in the form of an injected tracer, and observe their …

The ability to trace or identify specific molecules within a specific anatomic location provides
insight into metabolic pathways, tissue components, and tracing of solute transport …

Preclinical cardiovascular research using noninvasive radionuclide and hybrid imaging
systems has been extensively developed in recent years. Single photon emission computed …

Scintigraphy (positron emission tomography (PET) or single photon emission computed
tomography (SPECT) techniques) allows qualitative and quantitative measurement of …

SPECT is a rapidly changing field, and the past several years have produced new
developments in both hardware technology and image-processing algorithms. At the …

1. Introduction 287 2. Animal preparation and handling 287 3. Radiopharmaceuticals 288 4.
Pinhole-gated SPECT imaging 288 5. Data reconstruction 288 6. Data analysis 289 7 …

During the last decade we have observed a growing interest in in-vivo imaging techniques
for small animals. This is due to the necessity of studying biochemical processes at a …