Pretherapeutic comparative dosimetry of 177Lu-rhPSMA-7.3 and 177Lu-PSMA I&T in patients with metastatic castration-resistant prostate cancer

B Feuerecker, M Chantadisai, A Allmann… - Journal of Nuclear …, 2022 - Soc Nuclear Med
Radiohybrid prostate-specific membrane antigen (rhPSMA) ligands allow for labeling with
18F and radiometals for endoradiotherapy. rhPSMA-7.3 has been designated as a lead …

An intrapatient dosimetry comparison of 177Lu-rhPSMA-10.1 and 177Lu-PSMA-I&T in patients with metastatic castration-resistant prostate cancer

A Rinscheid, A Gäble, G Wienand, C Pfob… - Journal of Nuclear …, 2023 - Soc Nuclear Med
As the use of radioligand therapy moves earlier in the prostate cancer timeline, minimizing
the absorbed dose to normal organs while maintaining high tumor radiation doses becomes …

Radiation dosimetry for 177Lu-PSMA I&T in metastatic castration-resistant prostate cancer: absorbed dose in normal organs and tumor lesions

S Okamoto, A Thieme, J Allmann… - Journal of Nuclear …, 2017 - Soc Nuclear Med
Prostate-specific membrane antigen (PSMA)–targeted radioligand therapy is increasingly
used in metastatic castration-resistant prostate cancer. We aimed to estimate the absorbed …

Prostate-specific membrane antigen radioligand therapy using 177Lu-PSMA I&T and 177Lu-PSMA-617 in patients with metastatic castration-resistant prostate cancer …

C Schuchardt, J Zhang, HR Kulkarni… - Journal of Nuclear …, 2022 - Soc Nuclear Med
The objective of this study was to determine the safety, kinetics, and dosimetry of the 177Lu-
labeled prostate-specific membrane antigen (PSMA) small molecules 177Lu-PSMA I&T and …

Comparative preclinical biodistribution, dosimetry, and endoradiotherapy in metastatic castration-resistant prostate cancer using 19F/177Lu-rhPSMA-7.3 and 177Lu …

N Yusufi, A Wurzer, M Herz… - Journal of Nuclear …, 2021 - Soc Nuclear Med
Radiohybrid prostate-specific membrane antigen (rhPSMA) ligands are applicable as
radiochemical twins for both diagnostic PET imaging and endoradiotherapy. On the basis of …

Synthesis and preclinical evaluation of 177Lu-labeled radiohybrid PSMA ligands for endoradiotherapy of prostate cancer

A Wurzer, JP Kunert, S Fischer, V Felber… - Journal of Nuclear …, 2022 - Soc Nuclear Med
The prostate-specific membrane antigen (PSMA)–targeted radiohybrid (rh) ligand [177Lu]
Lu-rhPSMA-7.3 has recently been assessed in a pretherapeutic dosimetry study on prostate …

Dose calculations and dose-effect relationships in 177Lu-PSMA I&T radionuclide therapy for metastatic castration-resistant prostate cancer

S Barna, AR Haug, M Hartenbach, S Rasul… - Clinical nuclear …, 2020 - journals.lww.com
Methods The patients' age range was 74±7 years at the time of the investigated treatment
cycle, and the mean injected activity was 7416±218 MBq. Planar images at several time …

Dosimetry of 177Lu-PSMA-617 in metastatic castration-resistant prostate cancer: correlations between pretherapeutic imaging and whole-body tumor dosimetry with …

J Violet, P Jackson, J Ferdinandus… - Journal of Nuclear …, 2019 - Soc Nuclear Med
177Lu-prostate-specific membrane antigen (PSMA)–617 enables targeted delivery of β-
particle radiation to prostate cancer. We determined its radiation dosimetry and relationships …

[HTML][HTML] [161Tb] Tb-PSMA-617 radioligand therapy in patients with mCRPC: preliminary dosimetry results and intra-individual head-to-head comparison to [177Lu] Lu …

A Schaefer-Schuler, C Burgard, A Blickle, S Maus… - Theranostics, 2024 - ncbi.nlm.nih.gov
Rationale: Evaluation of alternative radionuclides for use in prostate-specific membrane
antigen (PSMA)-targeted radioligand therapy (RLT) is currently focusing on 161 Tb, which …

[HTML][HTML] Streamlined Schemes for Dosimetry of 177Lu-Labeled PSMA Targeting Radioligands in Therapy of Prostate Cancer

J Kurth, M Heuschkel, A Tonn, A Schildt… - Cancers, 2021 - mdpi.com
Simple Summary In patients with progressive metastasized castration-resistance prostate
cancer PSMA radioligand therapies have shown promising results regarding clinical safety …