Cocaine addiction is a disorder that still lacks diagnostic biomarkers or effective
pharmacotherapy. We present findings on a rat model of cocaine self-administration that …

Background Preclinical studies demonstrate that glutamate homeostasis in the striatum is
disrupted following cocaine exposure, including a decrease in metabotropic glutamate …

Cocaine addiction is a chronically relapsing disorder that is associated with harmful
consequences. Relapses occur frequently and effective pharmacotherapies are currently …

Cocaine self-administration decreases type 5 metabotropic glutamate receptor (mGluR5)
tissue concentrations in laboratory rats during early abstinence. These changes are thought …

Previous studies have shown significantly lower metabolism and functional activity in the
anterior cingulate cortex (ACC) of human cocaine addicts. The present study examined …

Cocaine addiction is characterized by overwhelming craving for the substance, which drives
its escalating use despite adverse consequences. Animal models suggest a disrupted …

Introduction The diagnosis of psychoactive substance use disorders has been based
primarily on descriptive, symptomatic checklist criteria. In opioid addiction, there are no …

Rationale Chronic cocaine exposure has been associated with progressive brain structural
and functional changes. Clarifying mechanisms underlying cocaine's progressive brain …

Mu-opioid receptor agonists alter brain glutamate (GLU) levels in laboratory animals. This
clinical study used proton magnetic resonance spectroscopy (1 H MRS) to examine regional …

Craving is a core symptom of cocaine use disorder and a major factor for relapse risk. To
date, there is no pharmacological therapy to treat this disease or at least to alleviate cocaine …