Folic acid has been frequently exploited to target attached drugs to cells that overexpress a
folate receptor (FR). Unfortunately, folic acid and folate-linked drugs bind equally well to …

Folate receptors are up-regulated on a variety of human cancers, including cancers of the
breast, ovaries, endometrium, lungs, kidneys, colon, brain, and myeloid cells of …

Frequent overexpression of the folate receptor (FR) on a variety of tumor types and on
activated macrophages makes this re-ceptor an interesting target for both imaging and …

The folate receptor (FR) is overexpressed on a variety of tumor types, whereas its
distribution in normal tissues and organs is highly limited. Exploration of the utility of the FR …

The vitamin folic acid (FA) enters cells either through a carrier protein, termed the reduced
folate carrier, or via receptor-mediated endocytosis facilitated by the folate receptor (FR) …

Folic acid was linked regioselectively through its α-and γ-carboxyl groups to 4-
fluorobenzylamine (FBA), and the α-and γ-FBA-folate regioisomers were evaluated for their …

The folate receptor (FR) is overexpressed in a wide variety of human tumors. In our study,
the multimeric concept was used to synthesize a dimeric folate derivative via a click reaction …

Conventional cancer treatment modalities have several limitations including lack of sufficient
efficacy, serious untoward toxicity, as well as innate and acquired drug resistance. In …

In order to avoid the toxicities associated with prescription drug use today, we have explored
novel methods for delivering drugs selectively to pathologic cells, thereby avoiding the …

The cell-membrane folate receptor is a potential molecular target for tumor-selective drug
delivery, including radiolabeled folate-chelate conjugates for diagnostic imaging. We review …