Apoptosis is a fundamental biologic process. Molecular imaging of apoptosis in vivo may
have important implications for clinical practice, assisting in early detection of disease …

Owing to the central role of apoptosis in many human diseases and the wide-spread
application of apoptosis-based therapeutics, molecular imaging of apoptosis in clinical …

Cancer is characterized by deregulation of cell proliferation and altered cell deathapoptosis,
which constitutes, in almost all instances, the minimal common platform upon which all …

Purpose We identified and validated [18 F]-CP18, a DEVD (the caspase 3 substrate
recognition motif) containing substrate-based compound as an imaging tracer for caspase-3 …

Purpose A novel caspase-3 substrate-based probe [18 F]-CP18 was evaluated as an in vivo
positron emission tomography (PET) imaging agent for monitoring apoptosis in tumors …

Purpose The substrate-based positron emission tomography (PET) tracer [18 F] CP18 is
capable of detecting the activity of caspase-3/7, two key executioner proteases in the …

Purpose In vivo detection of apoptosis is a diagnostic tool with potential clinical applications
in cardiology and oncology. Radiolabeled annexin-V (anxV) is an ideal probe for in vivo …

Purpose: Positron emission tomography (PET) imaging of apoptosis is very important for
early evaluation of tumor therapeutic efficacy. A stimuli-responsive probe based on the …

Clinical molecular imaging of apoptosis is a highly desirable yet unmet challenge. Here we
provide the first report on 18F-labeled 5-fluoropentyl-2-methyl-malonic acid (18F-ML-10), a …

Apoptosis, or programmed cell death, is involved in numerous human conditions including
neurodegenerative diseases, ischemic damage, autoimmune disorders and many types of …