Selectivity of 18F-FLT and 18F-FDG for differentiating tumor from inflammation in a rodent model

A van Waarde, DCP Cobben… - Journal of Nuclear …, 2004 - Soc Nuclear Med
Increased glucose metabolism of inflammatory tissues is the main source of false-positive
18F-FDG PET findings in oncology. It has been suggested that radiolabeled nucleosides …

Comparison of 18F-FDG, 18F-FET and 18F-FLT for differentiation between tumor and inflammation in rats

TS Lee, SH Ahn, BS Moon, KS Chun, JH Kang… - Nuclear medicine and …, 2009 - Elsevier
INTRODUCTION: The goal of this study was to compare the glucose analog, 2-[18F] fluoro-2-
deoxy-d-glucose ([18F]-FDG), the amino acid analog, o-(2-[18F] fluoroethyl)-l-tyrosine ([18F] …

Usefulness of 11C-methionine for differentiating tumors from granulomas in experimental rat models: a comparison with 18F-FDG and 18F-FLT

S Zhao, Y Kuge, M Kohanawa… - Journal of Nuclear …, 2008 - Soc Nuclear Med
Many clinical PET studies have shown that increased 18F-FDG uptake is not specific to
malignant tumors. 18F-FDG is also taken up in inflammatory lesions, particularly in …

Dual time point 18F-FDG PET imaging for differentiating malignant from inflammatory processes

H Zhuang, M Pourdehnad, ES Lambright… - Journal of Nuclear …, 2001 - Soc Nuclear Med
The aim of this study was to investigate the difference in the rates of FDG uptake between
malignant and inflammatory cells and processes. Methods: In vitro studies: 18F-FDG uptake …

Evaluation of 3′-deoxy-3′-18F-fluorothymidine for monitoring tumor response to radiotherapy and photodynamic therapy in mice

M Sugiyama, H Sakahara, K Sato… - Journal of Nuclear …, 2004 - Soc Nuclear Med
3′-Deoxy-3′-18F-fluorothymidine (18F-FLT) has been suggested as a new PET tracer for
imaging tumor proliferation. We investigated the use of 18F-FLT to monitor the response of …

Comparison of sigma-ligands and metabolic PET tracers for differentiating tumor from inflammation

A van Waarde, PL Jager, K Ishiwata… - Journal of Nuclear …, 2006 - Soc Nuclear Med
Novel radiopharmaceuticals for the detection of tumors and their metastases may be of
clinical interest if they are more tumor selective than 18F-FDG. Increased glucose …

3′-Deoxy-3′-[18F]Fluorothymidine as a New Marker for Monitoring Tumor Response to Antiproliferative Therapy in Vivo with Positron Emission Tomography

H Barthel, MC Cleij, DR Collingridge, OC Hutchinson… - Cancer research, 2003 - AACR
Deoxy-3′-[18F] fluorothymidine ([18F] FLT) has been proposed as a new marker for
imaging tumor proliferation by positron emission tomography (PET). The uptake of [18F] FLT …

Imaging proliferation in lung tumors with PET: 18F-FLT versus 18F-FDG

AK Buck, G Halter, H Schirrmeister… - Journal of nuclear …, 2003 - Soc Nuclear Med
Recently, the thymidine analog 3′-deoxy-3′-18F-fluorothymidine (FLT) was suggested for
imaging tumoral proliferation. In this prospective study, we examined whether 18F-FLT …

Comparison of 18F-FLT PET and 18F-FDG PET in esophageal cancer

HL van Westreenen, DCP Cobben… - Journal of Nuclear …, 2005 - Soc Nuclear Med
18F-FDG PET has gained acceptance for staging of esophageal cancer. However, FDG is
not tumor specific and false-positive results may occur by accumulation of FDG in benign …

PET imaging with 18F-FLT and thymidine analogs: promise and pitfalls

AF Shields - Journal of Nuclear Medicine, 2003 - Soc Nuclear Med
Medicine (1). Although the use of PET has exploded within the last few years, this has
primarily resulted from the application of 18F-FDG in oncology research and clinical …