99mTc-labeled divalent and tetravalent CC49 single-chain Fv's: novel imaging agents for rapid in vivo localization of human colon carcinoma
A Goel, J Baranowska-Kortylewicz… - Journal of Nuclear …, 2001 - Soc Nuclear Med
Radioimmunopharmaceutical agents enabling rapid high-resolution imaging, high tumor-to-
background ratios, and minimal immunogenicity are being sought for cancer diagnosis and …
background ratios, and minimal immunogenicity are being sought for cancer diagnosis and …
Single-Dose versus Fractionated Radioimmunotherapy of Human Colon Carcinoma Xenografts Using 131I-labeled Multivalent CC49 Single-chain Fvs
A Goel, S Augustine, J Baranowska-Kortylewicz… - Clinical cancer …, 2001 - AACR
The prospects of radiolabeled antibodies in cancer detection and therapy remain promising.
However, efforts to achieve cures, especially of solid tumors, with the systemic …
However, efforts to achieve cures, especially of solid tumors, with the systemic …
Genetically engineered tetravalent single-chain Fv of the pancarcinoma monoclonal antibody CC49: improved biodistribution and potential for therapeutic application
A Goel, D Colcher, J Baranowska-Kortylewicz… - Cancer Research, 2000 - AACR
Failure of radiolabeled monoclonal antibodies (MAbs) in the treatment of solid tumors, for
the most part, is a result of undesirable pharmacokinetics that lead to significant radiation …
the most part, is a result of undesirable pharmacokinetics that lead to significant radiation …
Pharmacokinetics and biodistribution of 177Lu-labeled multivalent single-chain Fv construct of the pancarcinoma monoclonal antibody CC49
SC Chauhan, M Jain, ED Moore, UA Wittel, J Li… - European Journal of …, 2005 - Springer
Abstract Purpose Lutetium-177 (177 Lu) is a radionuclide of interest for
radioimmunoimaging (RII) and radioimmunotherapy (RIT) on account of its short half-life …
radioimmunoimaging (RII) and radioimmunotherapy (RIT) on account of its short half-life …
Radioimmunotherapy of human colon cancer xenografts using a dimeric single-chain Fv antibody construct
G Pavlinkova, BJM Booth, SK Batra, D Colcher - Clinical cancer research, 1999 - AACR
Progress in the use of monoclonal antibodies (MAbs) for the treatment of solid tumors is
limited by a number of factors, including poor penetration of the labeled IgG molecule into …
limited by a number of factors, including poor penetration of the labeled IgG molecule into …
[PDF][PDF] Technetium-99m radiolabeling using a phage-derived single-chain Fv with a C-terminal cysteine
MJ Verhaar, PA Keep, RE Hawkins… - Journal of Nuclear …, 1996 - Soc Nuclear Med
Methods: We constructed a vector which enabled a free cysteineto be linked to the C-
terminus of scFvs. MFE-23, a scFv directed against carcinoembryonic antigen (CEA), was …
terminus of scFvs. MFE-23, a scFv directed against carcinoembryonic antigen (CEA), was …
Construction, binding properties, metabolism, and tumor targeting of a single-chain Fv derived from the pancarcinoma monoclonal antibody CC49
DE Milenic, T Yokota, DR Filpula, MAJ Finkelman… - Cancer Research, 1991 - AACR
CC49 is a “second generation” monoclonal antibody to B72. 3, which reacts with the
pancarcinoma antigen TAG-72. CC49 has been shown to efficiently target human colon …
pancarcinoma antigen TAG-72. CC49 has been shown to efficiently target human colon …
[PDF][PDF] Pharmacokinetics and biodistribution of engineered single-chain antibody constructs of MAb CC49 in colon carcinoma xenografts
G Pavlinkova, GW Beresford, BJM Booth… - Journal of Nuclear …, 1999 - Soc Nuclear Med
Results: The associationconstant (KA) for the intactCC49, dimencscFv (scFv) 2and
monomericscFv were 1.7 x 10@, 1.99 x lO9and0. 52 x 10@ M1 byScatchardanalysisand1 …
monomericscFv were 1.7 x 10@, 1.99 x lO9and0. 52 x 10@ M1 byScatchardanalysisand1 …
Radioiodinated versus radiometal-labeled anti–carcinoembryonic antigen single-chain Fv-Fc antibody fragments: optimal pharmacokinetics for therapy
Antibody fragments with optimized pharmacokinetic profiles hold potential for detection and
therapy of tumor malignancies. We studied the behavior of three anti–carcinoembryonic …
therapy of tumor malignancies. We studied the behavior of three anti–carcinoembryonic …
Binding characteristics and tumor targeting of a covalently linked divalent CC49 single‐chain antibody
GW Beresford, G Pavlinkova, BJM Booth… - … journal of cancer, 1999 - Wiley Online Library
Multivalency is a recognized means of increasing the functional affinity of single‐chain Fvs
(scFvs) for optimizing tumor uptake. A unique divalent single‐chain Fv protein [sc (Fv) 2] …
(scFvs) for optimizing tumor uptake. A unique divalent single‐chain Fv protein [sc (Fv) 2] …