Neutron-activatable holmium-containing mesoporous silica nanoparticles as a potential radionuclide therapeutic agent for ovarian cancer

AJ Di Pasqua, H Yuan, Y Chung, JK Kim… - Journal of Nuclear …, 2013 - Soc Nuclear Med
Mesoporous silica nanoparticles (MSNs) were explored as a carrier material for the stable
isotope 165Ho and, after neutron capture, its subsequent therapeutic radionuclide, 166Ho …

Tumor accumulation of neutron-activatable holmium-containing mesoporous silica nanoparticles in an orthotopic non-small cell lung cancer mouse model

AJ Di Pasqua, ML Miller, X Lu, L Peng, M Jay - Inorganica Chimica Acta, 2012 - Elsevier
Mesoporous silica MCM-41 nanoparticles containing the stable isotope holmium-165
(165Ho) were prepared by exposing the approximately 400nm particles to an aqueous …

Preparation of neutron-activatable holmium nanoparticles for the treatment of ovarian cancer metastases.

AJ Di Pasqua, JE Huckle, JK Kim, Y Chung… - Small (Weinheim an …, 2012 - europepmc.org
Nanoparticles containing stable holmium ((165) Ho) are prepared by nanotemplate
engineering and subsequently irradiated in a neutron flux to yield (166) Ho, a beta-emitting …

In-situ formation of holmium oxide in pores of Mesoporous Carbon Nanoparticles as substrates for neutron-activatable radiotherapeutics

J Kim, ZX Luo, Y Wu, X Lu, M Jay - Carbon, 2017 - Elsevier
Radionuclide therapy with nano-sized carriers is a very promising approach to treat various
types of cancer. The preparation of radioactive nanocarriers can be achieved with minimum …

In Vivo Integrity and Biological Fate of Chelator-Free Zirconium-89-Labeled Mesoporous Silica Nanoparticles

F Chen, S Goel, HF Valdovinos, H Luo, R Hernandez… - ACS …, 2015 - ACS Publications
Traditional chelator-based radio-labeled nanoparticles and positron emission tomography
(PET) imaging are playing vital roles in the field of nano-oncology. However, their long-term …

Folate-targeted nanoparticle delivery of chemo-and radiotherapeutics for the treatment of ovarian cancer peritoneal metastasis

ME Werner, S Karve, R Sukumar, ND Cummings… - Biomaterials, 2011 - Elsevier
Peritoneal metastasis is a major cause of morbidity and mortality in ovarian cancer. While
intraperitoneal chemotherapy and radiotherapy have shown favorable clinical results, both …

177Lu-Labeled Eu-Doped Mesoporous SiO2 Nanoparticles as a Theranostic Radiopharmaceutical for Colorectal Cancer

RS Viana, LAM Costa, AC Harmon… - ACS Applied Nano …, 2020 - ACS Publications
Colorectal cancer is one of the most significant types of cancer, ranking second in the
world's mortality cases. As colorectal cancer is often diagnosed at a late stage of disease …

[HTML][HTML] Hybrid nanomaterials based on iron oxide nanoparticles and mesoporous silica nanoparticles: overcoming challenges in current cancer treatments

MP Alvarez-Berríos, N Sosa-Cintron… - Journal of …, 2016 - hindawi.com
The current approaches used for the treatment of cancer face some clinical limitations such
as induction of severe side effects, multidrug resistance (MDR), and low specificity toward …

Preparation and characterization of multifunctional mesoporous silica nanoparticles for dual magnetic resonance and fluorescence imaging in targeted cancer therapy

SM Hsiao, BY Peng, YS Tseng, HT Liu… - Microporous and …, 2017 - Elsevier
We have constructed a theranostic drug delivery system, composed of a carrier and a drug.
Europium (Eu 3+) and gadolinium (Gd 3+) were doped into mesoporous silica nanoparticles …

Cancer-Cell-Specific Nuclear-Targeted Drug Delivery by Dual-Ligand-Modified Mesoporous Silica Nanoparticles.

L Xiong, X Du, F Kleitz, SZ Qiao - Small (Weinheim an der …, 2015 - europepmc.org
Mesoporous silica nanoparticles are modified with dual targeting ligands, ie, folic acid and
dexamethasone, to construct a cancer-cell-specific nuclear-targeted delivery system. The …