The poly-(adenosine diphosphate-ribose) polymerase (PARP) family of proteins participates
in numerous functions, most notably the DNA damage response. Cancer vulnerability to …

Fluorine 18 (18F) fluorthanatrace (18F-FTT) is a PET radiotracer for imaging poly
(adenosine diphosphate–ribose) polymerase-1 (PARP-1), an important target for a class of …

Purpose To demonstrate that positron emission tomography (PET) with fluorine 18 (18F)
fluorthanatrace (FTT) depicts activated poly (adenosine diphosphate–ribose) polymerase …

Poly (ADP-ribose) polymerase (PARP) inhibitors are increasingly being studied as cancer
drugs, as single agents, or as a part of combination therapies. Imaging of PARP using a …

Purpose: PARP inhibitors have become the standard-of-care treatment for homologous
recombination deficient (HRD) high-grade serous ovarian cancer (HGSOC). However, not …

Background Poly (ADP-ribose) polymerase (PARP) inhibitors are extensively studied and
used as anti-cancer drugs, as single agents or in combination with other therapies. Most …

Advanced ovarian cancer currently has few therapeutic options. Poly (ADP-ribose)
polymerase (PARP) inhibitors bind to nuclear PARP and trap the protein-inhibitor complex to …

Poly (ADP ribose) polymerase (PARP) enzymes generate poly (ADP ribose) post-
translational modifications on target proteins for an array of functions centering on DNA and …

BACKGROUND. Poly (ADP-ribose) polymerase (PARP) inhibitors are effective in a broad
population of patients with ovarian cancer; however, resistance caused by low enzyme …

The genetic code to life is balanced on a string of DNA that is under constant metabolic and
physical stress from environmental forces. Nearly all diseases have a genetic component …