[PDF][PDF] Antigen-binding site protection during radiolabeling leads to a higher immunoreactive fraction
AD Van den Abbeele, RA Aaronson… - Journal of Nuclear …, 1991 - Soc Nuclear Med
MATERIALS AND METHODS Antigen-Antibody System Affinity-purified goat anti-mouse IgO
(heavy and light chains) and rabbit anti-mouse IgG (heavy and light chains) at a …
(heavy and light chains) and rabbit anti-mouse IgG (heavy and light chains) at a …
[PDF][PDF] Distribution of radiolabeled human and mouse monoclonal IgM antibodies in murine models
SE Halpern, PL Hagan, A Chen… - Journal of nuclear …, 1988 - Soc Nuclear Med
RESULTS Figure 1shows the mouse distribution of three †œSe labeled human 1gM
MoAbs 4 hr following their iv administration. ThethreeMoAbshavevirtuallyiden tical …
MoAbs 4 hr following their iv administration. ThethreeMoAbshavevirtuallyiden tical …
Does the in vitro testing of the immunoreactivity of an antibody reflect its in vivo behavior
AD Van den Abbeele, RA Aaronson… - Journal of Nuclear …, 1988 - inis.iaea.org
[en] It has been assumed that radioimmunoassays (RIA) can be used as an in vitro test to
predict the integrity of radiolabeled antibody molecules. the effects of radioiodination of …
predict the integrity of radiolabeled antibody molecules. the effects of radioiodination of …
Radioimmunolocalization and selective delivery of radiation in a rat model system: comparison of intact and fragmented antibody.
KZ Walker, K Seymour-Munn, JE Towson… - Nuclear Medicine …, 1988 - europepmc.org
Monoclonal antibody (MoAb) fragments are known to have advantages over intact
immunoglobulins for radioimmunoscintigraphy. It is less clear whether they are as effective …
immunoglobulins for radioimmunoscintigraphy. It is less clear whether they are as effective …
[PDF][PDF] The characteristics of blood-borne radiolabels and the effect of anti-mouse IgG antibodies on localization of radiolabeled monoclonal antibody in cancer …
MV Pimm, AC Perkins, NC Armitage… - Journal of nuclear …, 1985 - Soc Nuclear Med
1311or 111ln was similar. A bi-phaalc decline of both radiolabeled preparations was
measuredwith initialhalf-lives0. 62 and 0.42 daysfor 1311and1 1Inlabelsandthenwith 1.85 …
measuredwith initialhalf-lives0. 62 and 0.42 daysfor 1311and1 1Inlabelsandthenwith 1.85 …
[PDF][PDF] Radioimmunodetection in cancer identification
DM Goldenberg, SM Larson - Journal of Nuclear Medicine, 1992 - Soc Nuclear Med
The form of antibody that appears to be ideal for imaging is related to the highest tumor-to-
background ratio achieved at the earliest time after antibody injection. When radioactive …
background ratio achieved at the earliest time after antibody injection. When radioactive …
Labeling and stability of radiolabeled antibody fragments by a direct 99mTc-labeling method
The in vitro labeling and stability of 99m Tc-labeled antibody Fab′ fragments prepared by a
direct labeling technique were evaluated. Eight antibody fragments derived from murine …
direct labeling technique were evaluated. Eight antibody fragments derived from murine …
[CITATION][C] Optimizing antibodies for use in nuclear medicine
AI Kassis - Journal of Nuclear Medicine, 1991 - Soc Nuclear Med
ity with the target tissue, and finally determining its in vivo stability, ki netics of biodistribution,
and target ing. In developing radiolabeling meth ods, particular attention is paid to …
and target ing. In developing radiolabeling meth ods, particular attention is paid to …
Labeling of monoclonal antibodies with radionuclides
KK Bhargava, SA Acharya - Seminars in Nuclear medicine, 1989 - Elsevier
Antibodies, specifically monoclonal antibodies, are potentially very useful and powerful
carriers of therapeutic agents to target tissues and diagnostic agents. The loading or …
carriers of therapeutic agents to target tissues and diagnostic agents. The loading or …
The binding parameters of radiolabelled monoclonal F (ab′)2 and Fab′ fragments relative to immunoglobulin G in reactions with surface-bound antigens
JG Fjeld, TE Michaelsen, K Nustad - European journal of nuclear medicine, 1992 - Springer
The binding parameters of iodine-125-labelled intact monoclonal immunoglobulin G (IgG), F
(ab′) 2 and Fab′ fragments were compared. The study was carried out with the two …
(ab′) 2 and Fab′ fragments were compared. The study was carried out with the two …