The thyroid transcription factors TTF-1 and Pax8 cooperate in the transcriptional activation of
thyroid-specific genes such as thyroglobulin (Tg), thyroperoxidase (TPO), and sodium/iodide …

Cotransfer of thyroid-specific transcription factor (TTF)-1 and Pax-8 gene to tumor cells,
resulting in the re-expression of iodide metabolism-associated proteins, such as sodium …

Loss of thyroid-specific gene expression and functions accompanied by loss of thyroid
transcription factors render them unresponsive to radioiodide therapy in poorly differentiated …

Thyroid-specific transcription factors TTF-1 and Pax-8 play a decisive role in the
determination and maintenance of cellular phenotype activating thyroglobulin (Tg) …

Alteration of the redox potential has been proposed as a mechanism influencing gene
expression. Reduced glutathione (GSH) is one of the cellular scavengers involved in the …

The mutant rat thyroid cell line FRTL-5/TA, isolated from a non-functional tumour which
originated spontaneously from wild-type FRTL-5 cells, shows autonomous TSH …

Objective Benign and malignant thyroid tumours are characterized by alterations of the
expression level of thyroid‐specific genes involved in the iodide metabolism. Imbalance in …

Abstract TTF-1 and PAX-8 are tissue-specific transcription factors expressed in the thyroid
follicular cells, contributing to the maintenance of the differentiated phenotype. In fact, it has …

Thyroid-enriched transcription factors, Pax-8 and TTF-1, are involved in the thyroid-specific
expression of thyroglobulin (TG) gene. Here we demonstrate redox regulation of both factors …

Thyrotropin (TSH), via its cyclic adenosine monophosphate (cAMP) signal, decreases
thyrotropin receptor (TSHR) gene expression in FRTL-5 thyroid cells, whereas it increases …