Biodistribution and blood metabolism of 1-11C-methyl-4-piperidinyl n-butyrate in humans: an imaging agent for in vivo assessment of butyrylcholinesterase activity …
A Roivainen, J Rinne, J Virta, T Järvenpää… - Journal of Nuclear …, 2004 - Soc Nuclear Med
1-11C-Methyl-4-piperidinyl n-butyrate (11C-MP4B) is a new radiopharmaceutical for the in
vivo assessment of butyrylcholinesterase (BuChE) activity using PET. To quantify in vivo …
vivo assessment of butyrylcholinesterase (BuChE) activity using PET. To quantify in vivo …
1-11C-methyl-4-piperidinyl-N-butyrate radiation dosimetry in humans by dynamic organ-specific evaluation
JR Virta, T Tolvanen, K Någren, A Brück… - Journal of Nuclear …, 2008 - Soc Nuclear Med
Deficits of cholinergic neurotransmission contribute to various neurologic and psychiatric
conditions. The neurotransmitter acetylcholine is hydrolyzed in the synaptic clefts by 2 …
conditions. The neurotransmitter acetylcholine is hydrolyzed in the synaptic clefts by 2 …
Impact of P-glycoprotein function on the brain kinetics of the weak substrate 11C-metoclopramide assessed with PET imaging in humans
PET with avid substrates of P-glycoprotein (ABCB1) provided evidence of the role of this
efflux transporter in effectively restricting the brain penetration of its substrates across the …
efflux transporter in effectively restricting the brain penetration of its substrates across the …
18F-SMBT-1: a selective and reversible PET tracer for monoamine oxidase-B imaging
R Harada, Y Hayakawa, M Ezura… - Journal of Nuclear …, 2021 - Soc Nuclear Med
Reactive astrocytes play a key role in the pathogenesis of various neurodegenerative
diseases. Monoamine oxidase-B (MAO-B) is one of the promising targets for the imaging of …
diseases. Monoamine oxidase-B (MAO-B) is one of the promising targets for the imaging of …
Whole-body distribution and metabolism of [N-methyl-11C](R)-1-(2-chlorophenyl)-N-(1-methylpropyl)-3-isoquinolinecarboxamide in humans; an imaging agent for …
Purpose 11 C-PK11195 is a radiopharmaceutical for in vivo assessment of peripheral
benzodiazepine receptor (PBR) activity using PET. We sought to clarify the metabolic fate of …
benzodiazepine receptor (PBR) activity using PET. We sought to clarify the metabolic fate of …
A rapid solid-phase extraction method for measurement of non-metabolised peripheral benzodiazepine receptor ligands,[18F] PBR102 and [18F] PBR111, in rat and …
A Katsifis, C Loc'h, D Henderson, T Bourdier… - Nuclear medicine and …, 2011 - Elsevier
OBJECTIVES: To develop a rapid and reliable method for estimating non-metabolised PBR
ligands fluoroethoxy ([18F] PBR102)-and fluoropropoxy ([18F] PBR111)-substituted 2-(6 …
ligands fluoroethoxy ([18F] PBR102)-and fluoropropoxy ([18F] PBR111)-substituted 2-(6 …
Radiation dosimetry of N-([11C]methyl)benperidol as determined by whole-body PET imaging of primates
JAV Antenor-Dorsey, R Laforest, SM Moerlein… - European journal of …, 2008 - Springer
Abstract Purpose N-([11 C] methyl) benperidol ([11 C] NMB) can be used for positron
emission tomography (PET) measurements of D 2-like dopamine receptor binding in vivo …
emission tomography (PET) measurements of D 2-like dopamine receptor binding in vivo …
Synthesis of 3-[18F] fluoromethyl-BTCP and evaluation as a potential PET radioligand for the dopamine transporter in baboons
M Ponchant, M Varastet, P Hantraye… - Nuclear medicine and …, 1993 - Elsevier
In an attempt to visualize in vivo the dopamine transporter and evaluate its potential as an
imaging tool for monitoring dopamine fiber degeneration by positron emission tomography …
imaging tool for monitoring dopamine fiber degeneration by positron emission tomography …
Metabolite analysis of [11C]flumazenil in human plasma: Assessment as the standardized value for quantitative PET studies
K Ishiwata, T Itou, M Ohyama, T Yamada… - Annals of nuclear …, 1998 - Springer
Abstract Analysis of carbon-11 labeled metabolites in plasma was carried out during
positron emission tomography (PET) studies with a central benzodiazepine receptor ligand …
positron emission tomography (PET) studies with a central benzodiazepine receptor ligand …
[PDF][PDF] Brain acetylcholinesterase activity: validation of a PET tracer in a rat model of Alzheimer's disease
T Irie, K Fukushi, H Namba, M Iyo… - Journal of Nuclear …, 1996 - Soc Nuclear Med
We developed three radioactive acetythc* ie anabgs— N@ 4C] meth@ 4-4-pip@
acetateff@ 4C] MP4A4, propionate@ C] MP4P) and@ obut@ te ff@ 4CJMP4IB) — …
acetateff@ 4C] MP4A4, propionate@ C] MP4P) and@ obut@ te ff@ 4CJMP4IB) — …