Study of 89Zr-pembrolizumab PET/CT in patients with advanced-stage non–small cell lung cancer

ALN Niemeijer, DE Oprea-Lager… - Journal of Nuclear …, 2022 - Soc Nuclear Med
The tumor programmed death ligand 1 (PD-L1) proportion score is the current method for
selecting non–small cell lung cancer (NSCLC) patients for single-agent treatment with …

PD-L1 PET/CT Imaging with Radiolabeled Durvalumab in Patients with Advanced-Stage Non–Small Cell Lung Cancer

J Smit, FJ Borm, ALN Niemeijer… - Journal of Nuclear …, 2022 - Soc Nuclear Med
Better biomarkers are needed to predict treatment outcome in non–small cell lung cancer
(NSCLC) patients treated with anti–programmed death-1/programmed death-ligand 1 (PD …

Early phase I study of a 99mTc-labeled anti–programmed death ligand-1 (PD-L1) single-domain antibody in SPECT/CT assessment of PD-L1 expression in non–small …

Y Xing, G Chand, C Liu, GJR Cook… - Journal of Nuclear …, 2019 - Soc Nuclear Med
Immunotherapy with checkpoint inhibitor programmed cell death 1 (PD-1)/programmed
death ligand-1 (PD-L1) antibodies demonstrates improvements in treatment of advanced …

[HTML][HTML] 89Zr-pembrolizumab imaging as a non-invasive approach to assess clinical response to PD-1 blockade in cancer

IC Kok, JS Hooiveld, PP van de Donk, D Giesen… - Annals of …, 2022 - Elsevier
Background Programmed cell death protein 1 (PD-1) antibody treatment is standard of care
for melanoma and non-small-cell lung cancer (NSCLC). Accurately predicting which patients …

Comparison of RECIST, iRECIST, and PERCIST for the evaluation of response to PD-1/PD-L1 blockade therapy in patients with non–small cell lung cancer

L Beer, M Hochmair, AR Haug, B Schwabel… - Clinical nuclear …, 2019 - journals.lww.com
Purpose The aim of this study was to compare the Response Evaluation Criteria in Solid
Tumors (RECIST) 1.1, the immune RECIST (iRECIST) criteria, and the Positron Emission …

[HTML][HTML] Tumor metabolic volume by 18F-FDG-PET as a prognostic predictor of first-line pembrolizumab for NSCLC patients with PD-L1 ≥ 50%

O Yamaguchi, K Kaira, K Hashimoto, A Mouri… - Scientific reports, 2020 - nature.com
There is a lack of markers for predicting favorable outcomes after pembrolizumab therapy in
patients with non-small cell lung cancer (NSCLC) with programmed death ligand-1 (PD-L1) …

Metabolic activity by 18F–FDG-PET/CT is predictive of early response after nivolumab in previously treated NSCLC

K Kaira, T Higuchi, I Naruse, Y Arisaka, A Tokue… - European journal of …, 2018 - Springer
Background Nivolumab, an anti-programmed death-1 (PD-1) antibody, is administered in
patients with previously treated non-small cell lung cancer. However, little is known about …

First-in-humans evaluation of a PD-L1–binding peptide PET radiotracer in non–small cell lung cancer patients

X Zhou, J Jiang, X Yang, T Liu, J Ding… - Journal of Nuclear …, 2022 - Soc Nuclear Med
68Ga-NOTA-WL12 is a peptide-based PET imaging agent. We conducted a first-in-human
study of 68Ga-NOTA-WL12 for PET to study the in vivo biodistribution, metabolism, radiation …

Comparison between 18F-FDG PET–based and CT-based criteria in non–small cell lung cancer Patients treated with nivolumab

G Rossi, M Bauckneht, C Genova… - Journal of Nuclear …, 2020 - Soc Nuclear Med
Because of the peculiar mechanism of action of immune checkpoint inhibitors (ICIs),
evaluation of the radiologic response to them in solid tumors presents many challenges. We …

[HTML][HTML] 18F-FDG uptake in PET/CT is a potential predictive biomarker of response to anti-PD-1 antibody therapy in non-small cell lung cancer

K Takada, G Toyokawa, Y Yoneshima, K Tanaka… - Scientific reports, 2019 - nature.com
To examine the association between 18F-fluorodeoxyglucose (18F-FDG) uptake in positron
emission tomography/computed tomography (PET/CT) and the response to anti …