Rational linker design to accelerate excretion and reduce background uptake of peptidomimetic PSMA-targeting hybrid molecules

AC Eder, M Schäfer, J Schmidt… - Journal of Nuclear …, 2021 - Soc Nuclear Med
The evolution of peptidomimetic hybrid molecules for preoperative imaging and guided
surgery targeting the prostate-specific membrane antigen (PSMA) significantly progressed …

[HTML][HTML] A new class of PSMA-617-based hybrid molecules for preoperative imaging and intraoperative fluorescence navigation of prostate cancer

AC Eder, J Matthias, M Schäfer, J Schmidt… - Pharmaceuticals, 2022 - mdpi.com
The development of PSMA-targeting low-molecular-weight hybrid molecules aims at
advancing preoperative imaging and accurate intraoperative fluorescence guidance for …

177Lu-labeled albumin-binder–conjugated PSMA-targeting agents with extremely high tumor uptake and enhanced tumor-to-kidney absorbed dose ratio

HT Kuo, KS Lin, Z Zhang, CF Uribe… - Journal of Nuclear …, 2021 - Soc Nuclear Med
The use of an albumin binder has been shown to improve tumor uptake of prostate-specific
membrane antigen (PSMA)–targeting radiotherapeutic agents. The aim of this study was to …

[HTML][HTML] Albumin-binding PSMA radioligands: Impact of minimal structural changes on the tissue distribution profile

LM Deberle, VJ Tschan, F Borgna, F Sozzi-Guo… - Molecules, 2020 - mdpi.com
The concept of using ibuprofen as an albumin-binding entity was recently demonstrated by
the development of [177Lu] Lu-Ibu-PSMA-01. In the present study, we designed a novel …

Albumin-binding PSMA ligands: optimization of the tissue distribution profile

M Benešová, CA Umbricht, R Schibli… - Molecular …, 2018 - ACS Publications
The prostate-specific membrane antigen (PSMA) has emerged as an attractive prostate
cancer associated target for radiotheragnostic application using PSMA-specific radioligands …

PSMA-11–derived dual-labeled PSMA inhibitors for preoperative PET imaging and precise fluorescence-guided surgery of prostate cancer

AC Baranski, M Schäfer, U Bauder-Wüst… - Journal of Nuclear …, 2018 - Soc Nuclear Med
Resection of tumors using targeted dual-modality probes combining preoperative imaging
with intraoperative guidance is of high clinical relevance and might considerably affect the …

The PSMA-11-derived hybrid molecule PSMA-914 specifically identifies prostate cancer by preoperative PET/CT and intraoperative fluorescence imaging

AC Eder, MA Omrane, S Stadlbauer, M Roscher… - European journal of …, 2021 - Springer
Resection of tumor tissue represents one of the standard curative treatment options for the
clinical management of prostate cancer [1]. However, intraoperative localization and precise …

Albumin-binding PSMA ligands: implications for expanding the therapeutic window

JM Kelly, A Amor-Coarasa, S Ponnala… - Journal of Nuclear …, 2019 - Soc Nuclear Med
Despite significant gains in the treatment of metastatic castration-resistant prostate cancer by
radioligands targeting prostate-specific membrane antigen (PSMA), 30% of patients never …

[HTML][HTML] Preclinical Evaluation of a New Series of Albumin-Binding 177Lu-Labeled PSMA-Based Low-Molecular-Weight Radiotherapeutics

S Boinapally, S Alati, Z Jiang, Y Yan, A Lisok, R Singh… - Molecules, 2023 - mdpi.com
Prostate-specific membrane antigen (PSMA)-based low-molecular-weight agents using beta
(β)-particle-emitting radiopharmaceuticals is a new treatment paradigm for patients with …

Effects of Linker Modification on Tumor-to-Kidney Contrast of 68Ga-Labeled PSMA-Targeted Imaging Probes

HT Kuo, J Pan, Z Zhang, J Lau, H Merkens… - Molecular …, 2018 - ACS Publications
68Ga-PSMA-11 is currently the most popular prostate-specific membrane antigen (PSMA)
radioligand used in the clinic to detect prostate cancer and metastases. However, the high …