73 Introduction: Aggregated tau proteins are one of the hallmarks of Alzheimer's disease
(AD), and there is a great need for further exploration of how tau accumulates and spreads …

629 Objectives: PET tracers for tau pathology in Alzheimer's disease (AD) are of increasing
interest as diagnostics and as markers of disease severity. However, there have been few …

The availability of tau PET radioligands enables quantitative assessment of tau density and
distribution in the human brain. We evaluated the kinetics of a novel radioligand, 18F-RO …

Background [18F]-AV-1451 is a PET tracer used to evaluation of neurofibrillary tau
pathology in vivo. It is still unknown what spatial pattern best characterizes an Alzheimer's …

Purpose The accumulation of misfolded tau is a common feature of several
neurodegenerative disorders, with Alzheimer's disease (AD) being the most common …

18F-PI-2620 is a PET tracer with high binding affinity for aggregated tau, a key pathologic
feature of Alzheimer disease (AD) and other neurodegenerative disorders. Preclinically, 18F …

The advent of PET ligands that bind tau pathology has enabled the quantification and
visualization of tau pathology in aging and in Alzheimer disease (AD). There is strong …

18F-PI-2620 is a next-generation tau PET tracer that has demonstrated ability to image the
spatial distribution of suspected tau pathology. The objective of this study was to assess the …

1541 Objectives: One of the current challenges in static tau PET imaging is the
establishment of a suitable reference region for count normalization and definition of …

140 Objectives [F-18]-T807 (also known as [F-18]-AV-1451) was reported (Xia et al., 2013)
as having high affinity and selectivity to the aggregated fibrillar form of tau pathology. Chien …