Myocardial metabolic and perfusion imaging is a vital tool for understanding the physiologic
consequences of heart failure. We used PET imaging to examine the longitudinal kinetics of …

We proposed that metabolic remodeling in the form of increased uptake of the myocardial
glucose analog 18F-FDG precedes and triggers the onset of severe contractile dysfunction …

Using longitudinal micro positron emission tomography (microPET)/computed tomography
(CT) studies, we quantified changes in myocardial metabolism and perfusion in …

Understanding the metabolic consequences of heart failure is important in evaluating
potential mechanisms for disease progression and assessing targets for therapies designed …

PET has become an important noninvasive imaging technique in cardiovascular research
for the characterization of mouse models in vivo. This modality offers unique insight into …

Background Quantitative myocardial fluorodeoxyglucose positron emission tomography
(FDG-PET) for assessing glucose uptake in vivo is reliable in normal rat heart. Objective To …

Background Cardiac metabolic changes in heart disease precede overt contractile
dysfunction. However, metabolism and function are not typically assessed together in …

Background Sustained pressure overload leads to changes in cardiac metabolism, function,
and structure. Both time course and causal relationships between these changes are not …

Molecular imaging by small-animal PET is an important noninvasive means to phenotype
transgenic mouse models in vivo. When investigating pathologies of the left ventricular (LV) …

This feasibility study was undertaken to determine whether kinetic modeling in conjunction
with small-animal PET could noninvasively quantify alterations in myocardial perfusion and …