1222 Introduction: Glioblastoma (GBM) is the most common primary adult brain malignancy
with an extremely poor prognosis and a median survival of fewer than 2 years. A key reason …

Glioblastoma (GBM) is the most common primary adult brain malignancy with an extremely
poor prognosis and a median survival of fewer than two years. A key reason for this high …

Purpose Glioblastoma (GBM) is a devastating disease. With the current treatment of surgery
followed by chemoradiation, outcomes remain poor, with median survival of only 15 months …

We investigated controlled blood-brain barrier (BBB) disruption using a low-frequency
clinical transcranial MRI-guided focused ultrasound (TcMRgFUS) device and evaluated …

The blood–brain-barrier (BBB) prevents the transport of most anticancer agents to the
central nervous system and restricts delivery to infiltrating brain tumors. The heterogeneous …

Purpose To demonstrate the feasibility of using focused ultrasound to enhance delivery of 1,
3-bis (2-chloroethyl)-1-nitrosourea (BCNU) to glioblastomas in rats with induced tumors and …

The presence of blood–brain barrier (BBB) and/or blood–brain–tumor barriers (BBTB) is one
of the main obstacles to effectively deliver therapeutics to our central nervous system (CNS); …

Blood–brain/blood–tumor barriers (BBB and BTB) and interstitial transport may constitute
major obstacles to the transport of therapeutics in brain tumors. In this study, we examined …

BACKGROUND The blood-brain barrier (BBB) is a major impediment to pharmacological
treatment of gliomas. Low-intensity pulsed ultrasound with concomitant administration of …

Glioblastoma is the most common intracranial malignancy in adults and carries a poor
prognosis. Chemotherapeutic treatment figures prominently in the management of primary …