Clinical studies have demonstrated the potential of radiometallated exendin-4 derivatives for
the imaging of glucagonlike peptide-1 receptor–overexpressing insulinomas. Recently …

Purpose Insulinomas are neuroendocrine tumours derived from pancreatic β-cells. The
glucagon-like peptide 1 receptor (GLP-1R) is expressed with a high incidence (> 90%) and …

Background Insulinoma is a neuroendocrine tumor derived from the β cells of pancreatic
islets. They are usually relatively inaccessible for surgical intervention. High expression …

Purpose Glucagon-like peptide type 1 (GLP-1) is an incretin peptide that augments glucose-
stimulated insulin release following oral consumption of nutrients. Its message is transmitted …

Strong overexpression of glucagonlike peptide-1 (GLP-1) receptors in human insulinoma
provides an attractive target for imaging. The first clinical trials demonstrated that GLP-1 …

GLP-1 receptors are ideal targets for preoperative imaging of benign insulinoma and for
quantifying the beta cell mass. The existing clinical tracers targeting GLP-1R are all agonists …

PET imaging of the glucagon-like peptide-1 receptor (GLP-1R) using radiolabeled exendin
is a promising imaging method to detect insulinomas. However, high renal accumulation of …

Introduction: The GLP-1 receptor plays an important role in glucose homeostasis and thus is
a very important target for diabetes therapy. The receptor is also overexpressed in …

Being highly expressed in insulinomas, the glucagonlike peptide-1 receptor (GLP-1R) is a
potential target for diagnosis, localization, and treatment with the radiolabeled GLP-1R …

Insulinomas are neuroendocrine tumors arising from the pancreatic beta cells. Currently,
surgical resection is the therapy of choice, and therefore, preoperative localization of …