MATERIALS AND METHODS Radiolabeling [123I] epidepride was prepared by
iododestannylation from N-[(lethyl-2-pyrrolidinyl)-methyl]-2, 3,-dimethoxy-5-(tributylstannyl) …

The iodine-123 labelled ligand benzamide epidepride was evaluated as a probe for in vivo
imaging of striatal and extrastriatal dopamine D 2 receptor sites in the human brain. Four …

SPECT Imaging of Dopamine D2 Receptors with 2â€-lodospiperone Page 1 Departments
ofNuclear Medicüze Brain Pathophysio1o@j', University, Kyoto, Japan Sciences and …

RESULTS Both radiopharmaceuticals were well tolerated except for minor irritation from the
ethanol vehicle during the 123I-epidepride infusion. Visually, the I23l-epidepride scans pro …

Iodine-123 labelled epidepride is a novel radiopharmaceutical for the study of cerebral
dopamine D 2 receptors using single-photon emission tomography (SPET). A lipophilic …

Dopamine D2 Receptor Ligand Page 1 tive disorders (6) and tardive dyskinesia (7). The
extremely high specificity and affinity of epidepride for the dopamine D2 receptor allows …

ÖPECT imaging of dopamine D2-receptors using I23l-labeled benzamide analogs such as
[I23l] iodobenzamide (IBZM) and [I23l] iodobenzofuran (IBF) is a potentially useful tool to …

The regional brain distribution and pharmacological specificity of three high affinity tracers
for the dopamine (DA) D 2 receptor:[123 I] IBF,[123 I] epidepride, and [123 I] 2′-ISP were …

Methods: Multilinear regression analysis (MLRA) and graphical analysis (GA) using plasma
parent (P) plus metabolite (M) activities as input and time activities of receptor-free (RF …

Epidepride {(S)-(−)-N-([1-ethyl-2-pyrrolidinyl] methyl)-5-iodo-2, 3-dimethoxybenzamide}
binds with a picomolar affinity (Ki= 24 pM) to the dopamine D2 receptor. Iodine-123-labeled …