[11C] PK11195-PET to image neuroinflammation in focal epilepsy
A Maoz, S Vallabhajosula, M Ichise, S Goldsmith… - 2011 - Soc Nuclear Med
1203 Objectives An association between neuroinflammation and epilepsy is increasingly
recognized. There is increasing evidence that seizure-related microglial activation …
recognized. There is increasing evidence that seizure-related microglial activation …
Imaging inflammation in a patient with epilepsy due to focal cortical dysplasia
T Butler, M Ichise, AF Teich, E Gerard… - Journal of …, 2013 - Wiley Online Library
ABSTRACT BACKGROUND AND PURPOSE Evidence from animal models and
examination of human epilepsy surgery specimens indicates that inflammation plays an …
examination of human epilepsy surgery specimens indicates that inflammation plays an …
Imaging brain inflammation: if we can see it, maybe we can treat it
JA French - Epilepsy currents, 2016 - journals.sagepub.com
Imaging Brain Inflammation could potentially represent a novel therapeutic intervention for
treatment resistant epilepsy. In fact, at least one intervention—an interleukin-converting …
treatment resistant epilepsy. In fact, at least one intervention—an interleukin-converting …
Quantitative longitudinal imaging of activated microglia as a marker of inflammation in the pilocarpine rat model of epilepsy using [11C]-(R)-PK11195 PET and MRI
J Yankam Njiwa, N Costes, C Bouillot… - Journal of Cerebral …, 2017 - journals.sagepub.com
Inflammation may play a role in the development of epilepsy after brain insults.[11C]-(R)-
PK11195 binds to TSPO, expressed by activated microglia. We quantified [11C]-(R) …
PK11195 binds to TSPO, expressed by activated microglia. We quantified [11C]-(R) …
Increased in vivo expression of an inflammatory marker in temporal lobe epilepsy
J Hirvonen, W Kreisl, M Fujita, I Dustin, O Khan… - 2011 - Soc Nuclear Med
13 Objectives Epilepsy may be associated with inflammation. Translocator protein 18 kDa
(TSPO), a marker of inflammation, is increased in vitro in surgical samples from patients with …
(TSPO), a marker of inflammation, is increased in vitro in surgical samples from patients with …
Multimodal evaluation of neuroinflammation-associated changes during epileptogenesis using small animal PET and MRI.
J Bankstahl, P Bascunana, M Brackhan, I Leiter, T Ross… - 2017 - Soc Nuclear Med
206 Objectives: Neuroinflammation has been suggested to be a key patho-mechanism of
epileptogenesis, ie the gradual process that leads to epilepsy. Our objective is to identify …
epileptogenesis, ie the gradual process that leads to epilepsy. Our objective is to identify …
Serial quantitative TSPO-targeted PET reveals peak microglial activation up to 2 weeks after an epileptogenic brain insult
M Brackhan, P Bascuñana, JM Postema… - Journal of Nuclear …, 2016 - Soc Nuclear Med
Experimental and clinical evidence suggests that neuroinflammation, triggered by
epileptogenic insults, contributes to seizure development. We used translocator protein …
epileptogenic insults, contributes to seizure development. We used translocator protein …
[HTML][HTML] PET imaging of brain inflammation during early epileptogenesis in a rat model of temporal lobe epilepsy
S Dedeurwaerdere, PD Callaghan, T Pham… - EJNMMI research, 2012 - Springer
Background Recently, inflammatory cascades have been suggested as a target for epilepsy
therapy. Positron emission tomography (PET) imaging offers the unique possibility to …
therapy. Positron emission tomography (PET) imaging offers the unique possibility to …
[18F]GE180 positron emission tomographic imaging indicates a potential double‐hit insult in the intrahippocampal kainate mouse model of temporal lobe epilepsy
M Brackhan, P Bascuñana, TL Ross, FM Bengel… - …, 2018 - Wiley Online Library
Objective Accumulating evidence suggests that brain inflammation, elicited by epileptogenic
insults, is involved in epilepsy development. Noninvasive nuclear imaging of brain …
insults, is involved in epilepsy development. Noninvasive nuclear imaging of brain …
Neuroinflammation in neocortical epilepsy measured by PET imaging of translocator protein
LP Dickstein, JS Liow, A Austermuehle, S Zoghbi… - …, 2019 - Wiley Online Library
Objectives Neuroinflammation, implicated in epilepsy, can be imaged in humans with
positron emission tomography (PET) ligands for translocator protein 18 kDa (TSPO) …
positron emission tomography (PET) ligands for translocator protein 18 kDa (TSPO) …