Multi-step, remote synthesis of 6-[18F] fluorodopamine via nucleophilic aromatic substitution

A Vavere, YS Ding, S Snyder - 2012 - Soc Nuclear Med
1481 Objectives 6-[18 F] fluorodopamine ([18 F] FDA) is a catecholamine that is actively
taken into cells via norepinephrine transporters and is useful in PET imaging of …

Efficient automated syntheses of high specific activity 6‐[18F]fluorodopamine using a diaryliodonium salt precursor

KD Neumann, L Qin, AL Vāvere, B Shen… - Journal of Labelled …, 2016 - Wiley Online Library
6‐[18F] Fluorodopamine (6‐[18F] F‐DA) is a positron emission tomography
radiopharmaceutical used to image sympathetic cardiac innervation and neuroendocrine …

Improved, one‐pot synthesis of 6‐[18F]fluorodopamine and quality control testing for use in patients with neuroblastoma

AL Vāvere, KD Neumann, ER Butch… - Journal of Labelled …, 2018 - Wiley Online Library
6‐[18F] Fluorodopamine ([18F] F‐DA) is taken into cells via the norepinephrine transporter
(NET). Recent [18F] F‐DA positron emission tomography–computed tomography (PET‐CT) …

Synthesis and preliminary validation of 6-[18F]-Fluorodopamine ([18F] FDA) as a PET tracer for neuroblastoma

A Vavere, E Butch, B Shulkin, S Snyder - 2014 - Soc Nuclear Med
1410 Objectives Studies have shown better visualization of small sites of
pheochromocytoma with [18 18F] FDA over [123] MIBG.[18 F] FDA accumulates via the …

Validation of a nucleophilic synthesis platform for clinical application of [18F] fluorodopa

S Moerlein, C Bognar, G Gaehle, R Oyama, S Schwarz… - 2017 - Soc Nuclear Med
255 Objectives: 6-[18 F] Fluorodopa (FDOPA) is useful for PET studies of movement
disorders like Parkinson disease and oncological conditions like neuroblastoma. Fdopa is …

New rapid fluorination process for the production of carrier free-F-18 6-[18F] FDA and 6-[18F]-L-DOPA

K Neumann, L Qin, A Vavere, S Snyder, S DiMagno - 2012 - Soc Nuclear Med
Abstract No. 71 Objectives 6-[18F]-Fluorodopamine (6-[18F] FDA) has been shown to be a
promising imaging biomarker of neuroendocrine tumors. 6-[18F]-L-DOPA has been shown …

Synthesis of high specific activity [18F] FDOPA using a synthesizing device with a user-configurable cassette

K Aita, A Ohnishi, G Akamatsu, M Sasaki, M Senda - 2016 - Soc Nuclear Med
1812 Objectives 6-[18F] fluoro-L-DOPA ([18F] FDOPA) is a useful PET tracer for the
evaluation of presynaptic dopaminergic function in diagnosis and research.[18F] FDOPA …

High yield 18F-FDOPA using nucleophilic synthesis in a PET clinical study

E Pellerin - 2016 - Soc Nuclear Med
2695 Objectives To evaluate the high activity production of 18F-FDOPA using a cassette
based nucleophilic radiosynthesis and HPLC purification using the Trasis AllinOne …

Novel electrophilic synthesis of 6-[18F]fluorodopamine and comprehensive biological evaluation

O Eskola, TJ Grönroos, A Naum, P Marjamäki… - European journal of …, 2012 - Springer
Abstract Purpose 6-[18 F] Fluorodopamine (4-(2-aminoethyl)-5-[18 F] fluorobenzene-1, 2-
diol, 6-[18 F] FDA) is a tracer for imaging sympathetically innervated tissues. Previous …

[HTML][HTML] Advances in the automated synthesis of 6-[18F]Fluoro-L-DOPA

ÂCB Neves, I Hrynchak, I Fonseca, VHP Alves… - EJNMMI radiopharmacy …, 2021 - Springer
Abstract The neurotracer 6-[18 F] FDOPA has been, for many years, a powerful tool in PET
imaging of neuropsychiatric diseases, movement disorders and brain malignancies. More …