Imaging diagnostic and therapeutic targets: steroid receptors in breast cancer

AM Fowler, AS Clark… - Journal of Nuclear …, 2016 - Soc Nuclear Med
Estrogen receptor alpha (ERα) and progesterone receptor (PR) are important steroid
hormone receptor biomarkers used to determine prognosis and to predict benefit from …

Recent advances in imaging steroid hormone receptors in breast cancer

M Kumar, K Salem, AJ Tevaarwerk… - Journal of Nuclear …, 2020 - Soc Nuclear Med
Estrogen receptor (ER) and progesterone receptor (PR) are important prognostic and
predictive biomarkers in breast cancer. PET using ER-and PR-specific radioligands enables …

Steroid receptor imaging in breast cancer

JM Beauregard, É Turcotte, F Bénard - PET clinics, 2006 - pet.theclinics.com
Many breast cancers express high levels of estrogen receptors (ER) or progesterone
receptors (PR), which have both been linked with the pathogenesis of this disease. Estrogen …

[PDF][PDF] Clinical potential of estrogen and progesterone receptor imaging

HM Linden, LM Peterson, AM Fowler - PET clinics, 2018 - Elsevier
Molecular imaging using FES and FFNP PET can assess in vivo function of steroid hormone
receptors in breast cancer. These experimental agents have been tested in many single …

Breast cancer: evaluating tumor estrogen receptor status with molecular imaging to increase response to therapy and improve patient outcomes

BJ Grabher - Journal of Nuclear Medicine Technology, 2020 - Soc Nuclear Med
Current statistics show there are 3.5 million women in the United States living with breast
cancer today, and approximately 330,000 new cases are diagnosed each year. Of these …

Nuclear imaging of hormonal receptor status in breast cancer: a tool for guiding endocrine treatment and drug development

EFJ De Vries, MG Rots… - Current cancer drug …, 2007 - ingentaconnect.com
Breast cancer is a commonly occurring disease in women and a major cause of morbidity
and mortality. In the past decades, the development of medical endocrine therapies has led …

Small-animal PET of steroid hormone receptors predicts tumor response to endocrine therapy using a preclinical model of breast cancer

AM Fowler, SR Chan, TL Sharp, NM Fettig… - Journal of Nuclear …, 2012 - Soc Nuclear Med
Estrogen receptor-α (ERα) and progesterone receptor (PR) are expressed in most human
breast cancers and are important predictive factors for directing therapy. Because of de novo …

PET imaging of steroid receptor expression in breast and prostate cancer

GAP Hospers, FA Helmond… - Current …, 2008 - ingentaconnect.com
The vast majority of breast and prostate cancers express specific receptors for steroid
hormones, which play a pivotal role in tumor progression. Because of the efficacy of …

Androgen and estrogen receptor imaging in metastatic breast cancer patients as a surrogate for tissue biopsies

CM Venema, LH Mammatas, CP Schröder… - Journal of Nuclear …, 2017 - Soc Nuclear Med
In addition to the well-known estrogen receptor (ER) and human epidermal growth factor
receptor 2, the androgen receptor (AR) is also a potential drug target in breast cancer …

[HTML][HTML] Determination of binding affinity of molecular imaging agents for steroid hormone receptors in breast cancer

K Salem, M Kumar, KC Kloepping… - American Journal of …, 2018 - ncbi.nlm.nih.gov
Abstract 16α-[18 F] Fluoro-17β-estradiol ([18 F] FES) and 21-[18 F]-Fluoro-16α, 17α-[(R)-(1'-
α-furylmethylidene) dioxyl]-19-norpregn-4-ene-3, 20-dione ([18 F] FFNP) are being …