A systematic approach for developing bacteria-specific imaging tracers
The modern patient is increasingly susceptible to bacterial infections including those due to
multidrug-resistant organisms (MDROs). Noninvasive whole-body analysis with pathogen …
multidrug-resistant organisms (MDROs). Noninvasive whole-body analysis with pathogen …
[HTML][HTML] An update on radiotracer development for molecular imaging of bacterial infections
MM Welling, AW Hensbergen, A Bunschoten… - Clinical and …, 2019 - Springer
Background Bacterial infections are still a major global healthcare problem. To combat the
increasing antimicrobial resistance, early diagnosis of bacterial infections—including the …
increasing antimicrobial resistance, early diagnosis of bacterial infections—including the …
[HTML][HTML] Imaging Active Infection in vivo Using D-Amino Acid Derived PET Radiotracers
KD Neumann, JE Villanueva-Meyer, CA Mutch… - Scientific reports, 2017 - nature.com
Occult bacterial infections represent a worldwide health problem. Differentiating active
bacterial infection from sterile inflammation can be difficult using current imaging tools …
bacterial infection from sterile inflammation can be difficult using current imaging tools …
[HTML][HTML] Kit-based synthesis of 2-deoxy-2-[18F]-fluoro-d-sorbitol for bacterial imaging
Clinically available imaging tools for diagnosing infections rely on structural changes in the
affected tissues. They therefore lack specificity and cannot differentiate between oncologic …
affected tissues. They therefore lack specificity and cannot differentiate between oncologic …
Validation of 2-18F-fluorodeoxysorbitol as a potential radiopharmaceutical for imaging bacterial infection in the lung
J Li, H Zheng, R Fodah, JM Warawa… - Journal of Nuclear …, 2018 - Soc Nuclear Med
2-18F-fluorodeoxysorbitol (18F-FDS) has been shown to be a promising agent with high
selectivity and sensitivity in imaging bacterial infection. The objective of our study was to …
selectivity and sensitivity in imaging bacterial infection. The objective of our study was to …
[HTML][HTML] Radiochemical approaches to imaging bacterial infections: intracellular versus extracellular targets
JD Northrup, RH Mach, MA Sellmyer - International Journal of Molecular …, 2019 - mdpi.com
The discovery of penicillin began the age of antibiotics, which was a turning point in human
healthcare. However, to this day, microbial infections are still a concern throughout the …
healthcare. However, to this day, microbial infections are still a concern throughout the …
Imaging Enterobacteriaceae infection in vivo with 18F-fluorodeoxysorbitol positron emission tomography
The Enterobacteriaceae are a family of rod-shaped Gram-negative bacteria that normally
inhabit the gastrointestinal tract and are the most common cause of Gram-negative bacterial …
inhabit the gastrointestinal tract and are the most common cause of Gram-negative bacterial …
[HTML][HTML] PET radiopharmaceuticals for specific bacteria imaging: a systematic review
Background: Bacterial infections are still one of the main factors associated with mortality
worldwide. Many radiopharmaceuticals were developed for bacterial imaging, both with …
worldwide. Many radiopharmaceuticals were developed for bacterial imaging, both with …
Radiotracer development for bacterial imaging
Bacterial infections remain a major threat to humanity and are a leading cause of death and
disability. Antimicrobial resistance has been declared as one of the top ten threats to human …
disability. Antimicrobial resistance has been declared as one of the top ten threats to human …
[HTML][HTML] Preclinical Research highlighting contemporary targeting mechanisms of radiolabelled compounds for PET based infection imaging
It is important to constantly monitor developments in the preclinical imaging arena of
infection. Firstly, novel radiopharmaceuticals with the correct characteristics must be …
infection. Firstly, novel radiopharmaceuticals with the correct characteristics must be …