First-in-human PET imaging and estimated radiation dosimetry of L-[5-11C]-glutamine in patients with metastatic colorectal cancer
AS Cohen, J Grudzinski, GT Smith… - Journal of Nuclear …, 2022 - Soc Nuclear Med
Altered metabolism is a hallmark of cancer. In addition to glucose, glutamine is an important
nutrient for cellular growth and proliferation. Noninvasive imaging via PET may help facilitate …
nutrient for cellular growth and proliferation. Noninvasive imaging via PET may help facilitate …
Pharmacokinetic assessment of 18F-(2S, 4R)-4-fluoroglutamine in patients with cancer
18F-(2S, 4R)-4-fluoroglutamine (18F-FGln) is an investigational PET radiotracer for imaging
tumor glutamine flux and metabolism. The aim of this study was to investigate its …
tumor glutamine flux and metabolism. The aim of this study was to investigate its …
PET imaging of glutamine metabolism in a clinical trial of metastatic colorectal cancer
A Cohen, A Payne, G Smith, J Whisenant, T Peterson… - 2020 - Soc Nuclear Med
630 Background: Colorectal cancer (CRC) is the second leading cause of cancer deaths in
the United States. Targeted therapies such as epidermal growth factor receptor (EGFR) …
the United States. Targeted therapies such as epidermal growth factor receptor (EGFR) …
PET imaging of glutaminolysis in tumors by 18F-(2S, 4R) 4-fluoroglutamine
BP Lieberman, K Ploessl, L Wang, W Qu… - Journal of nuclear …, 2011 - Soc Nuclear Med
Changes in gene expression, metabolism, and energy requirements are hallmarks of cancer
growth and self-sufficiency. Upregulation of the PI3K/Akt/mTor pathway in tumor cells has …
growth and self-sufficiency. Upregulation of the PI3K/Akt/mTor pathway in tumor cells has …
Metabolic imaging of glutamine in cancer
L Zhu, K Ploessl, R Zhou, D Mankoff… - Journal of Nuclear …, 2017 - Soc Nuclear Med
Glucose and glutamine are the most abundant nutrients for producing energy and building
blocks in normal and tumor cells. Increased glycolysis in tumors, the Warburg Effect, is the …
blocks in normal and tumor cells. Increased glycolysis in tumors, the Warburg Effect, is the …
In Vivo PET Assay of Tumor Glutamine Flux and Metabolism: In-Human Trial of 18F-(2S,4R)-4-Fluoroglutamine
MPS Dunphy, JJ Harding, S Venneti, H Zhang… - Radiology, 2018 - pubs.rsna.org
Purpose To assess the clinical safety, pharmacokinetics, and tumor imaging characteristics
of fluorine 18–(2S, 4R)-4-fluoroglutamine (FGln), a glutamine analog radiologic imaging …
of fluorine 18–(2S, 4R)-4-fluoroglutamine (FGln), a glutamine analog radiologic imaging …
Imaging brain metastasis patients with 18F-(2S, 4R)-4-fluoroglutamine
X Xu, H Zhu, F Liu, Y Zhang, J Yang… - Clinical Nuclear …, 2018 - journals.lww.com
Purpose There is a need for an alternative PET probe, which does not show normal brain
tissue uptake in the evaluation of metastasis to the brain. Therefore, we investigate the …
tissue uptake in the evaluation of metastasis to the brain. Therefore, we investigate the …
Preparation and characterization of L-[5-11C]-glutamine for metabolic imaging of tumors
W Qu, S Oya, BP Lieberman, K Ploessl… - Journal of Nuclear …, 2012 - Soc Nuclear Med
Recently, there has been a renewed interest in the study of tumor metabolism above and
beyond the Warburg effect. Studies on cancer cell metabolism have provided evidence that …
beyond the Warburg effect. Studies on cancer cell metabolism have provided evidence that …
Kinetic modeling of 18F-(2S, 4R) 4-fluoroglutamine in mouse models of breast cancer to estimate glutamine pool size as an indicator of tumor glutamine metabolism
V Viswanath, R Zhou, H Lee, S Li… - Journal of Nuclear …, 2021 - Soc Nuclear Med
The PET radiotracer 18F-(2 S, 4 R) 4-fluoroglutamine (18F-Gln) reflects glutamine transport
and can be used to infer glutamine metabolism. Mouse xenograft studies have …
and can be used to infer glutamine metabolism. Mouse xenograft studies have …
PET Imaging of 18F-(2S,4R)4-Fluoroglutamine Accumulation in Breast Cancer: From Xenografts to Patients
F Liu, X Xu, H Zhu, Y Zhang, J Yang… - Molecular …, 2018 - ACS Publications
Sustaining the growth of tumor cells requires extra energy and metabolic building blocks. In
addition to consuming glucose, glutamine may play the role as an alternative source of …
addition to consuming glucose, glutamine may play the role as an alternative source of …