Assays of human postmortem brain tissue have revealed that smokers have greater
densities of high-affinity nicotinic acetylcholine receptors (nAChRs) in several brain regions …

Our group recently reported that smoking a regular cigarette (1.2–1.4 mg nicotine) resulted
in 88% occupancy of brain α4β2* nicotinic acetylcholine receptors (nAChRs). However, this …

Noninvasive imaging of nicotinic acetylcholine receptors (nAChRs) in the human brain in
vivo is critical for elucidating the role of these receptors in normal brain function and in the …

We evaluated (−)-2-(6-[18F] fluoro-2, 3′-bipyridin-5′-yl)-7-methyl-7-aza-bicyclo [2.2. 1]
heptane (18F-AZAN), a novel radiotracer that binds to α4β2 nicotinic acetylcholine receptors …

Context 2-[18 F] fluoro-3-(2 (S)-azetidinylmethoxy) pyridine (2-FA-85380, abbreviated as 2-
FA) is a recently developed radioligand that allows for visualization of brain α 4 β 2* nicotinic …

2-18F-Fluoro-3-[2 (S)-2-azetidinylmethoxy] pyridine (2-18F-fluoro-A-85380) is a PET
radioligand that is specific for nicotinic acetylcholine receptors (nAChRs) and has a high …

Purpose The α 7 nicotinic acetylcholine receptor (nAChR) is implicated in many
neuropsychiatric disorders, making it an important target for positron emission tomography …

There are only 2 currently available radioligands, 2-18F-FA and 6-18F-FA, for quantitative
PET of the main cerebral subtype of nicotinic acetylcholine receptors (α4β2-nAChRs) in …

5-123I-iodo-85380 (123I-5-IA) is used to quantitate high-affinity nicotinic acetylcholine
receptors (β2-nAChRs) on human SPECT scans. The primary outcome measure is VT/f P …

The nicotinic acetylcholine receptors (nAChR) are involved in functions such as learning,
memory, and antinociception (Sahakian et al., 1989; Marubio et al., 1999). It has been …