11C-(R)-PK11195 PET imaging of microglial activation and response to minocycline in zymosan-treated rats

AK Converse, EC Larsen, JW Engle… - Journal of Nuclear …, 2011 - Soc Nuclear Med
We sought to advance methodology for studying microglial activation and putative
therapeutic downregulation in response to minocycline by means of noninvasive in vivo …

PET visualization of microglia in multiple sclerosis patients using [11C]PK11195

JC Debruyne, J Versijpt, KJ Van Laere… - European journal of …, 2003 - Wiley Online Library
Activated microglia are involved in the immune response of multiple sclerosis (MS). The
peripheral benzodiazepine receptor (PBR) is expressed on microglia and up‐regulated after …

PET imaging of demyelination and remyelination in the cuprizone mouse model for multiple sclerosis: a comparison between [11C] CIC and [11C] MeDAS

D de Paula Faria, EFJ de Vries, JWA Sijbesma… - Neuroimage, 2014 - Elsevier
Multiple Sclerosis (MS) is a neurodegenerative disease characterized by demyelinated
lesions. PET imaging using specific myelin radioligands might solve the lack of a specific …

PET imaging of focal demyelination and remyelination in a rat model of multiple sclerosis: comparison of [11C]MeDAS, [11C]CIC and [11C]PIB

D de Paula Faria, S Copray, JWA Sijbesma… - European journal of …, 2014 - Springer
Purpose In this study, we compared the ability of [11 C] CIC,[11 C] MeDAS and [11 C] PIB to
reveal temporal changes in myelin content in focal lesions in the lysolecithin rat model of …

In vivo detection of diffuse inflammation in secondary progressive multiple sclerosis using PET imaging and the radioligand 11C-PK11195

E Rissanen, J Tuisku, J Rokka… - Journal of Nuclear …, 2014 - Soc Nuclear Med
Patients with secondary progressive multiple sclerosis (SPMS) are lacking efficient
medication to slow down the progression of their disease. PET imaging holds promise as a …

[18F]DPA-714 PET Imaging of AMD3100 Treatment in a Mouse Model of Stroke

Y Wang, X Yue, DO Kiesewetter, Z Wang… - Molecular …, 2014 - ACS Publications
Chemokine receptor 4 and stromal-cell-derived factor 1 have been found to be related to the
initiation of neuroinflammation in ischemic brain. Herein, we aimed to monitor the changes …

[HTML][HTML] [11C]-DPA-713 and [18F]-DPA-714 as New PET Tracers for TSPO: A Comparison with [11C]-(R)-PK11195 in a Rat Model of Herpes Encephalitis

J Doorduin, HC Klein, RA Dierckx, M James… - Molecular imaging and …, 2009 - Springer
Background Activation of microglia cells plays an important role in neurological diseases.
Positron emission tomography (PET) with [11 C]-(R)-PK11195 has already been used to …

Evaluation of the effect of fingolimod treatment on microglial activation using serial PET imaging in multiple sclerosis

M Sucksdorff, E Rissanen, J Tuisku… - Journal of Nuclear …, 2017 - Soc Nuclear Med
Traditionally, multiple sclerosis (MS) has been considered a white matter disease with focal
inflammatory lesions. It is, however, becoming clear that significant pathology, such as …

Effect of cyclosporin A administration on the biodistribution and multipinhole μSPECT imaging of [123I]R91150 in rodent brain

P Blanckaert, I Burvenich, S Staelens… - European journal of …, 2009 - Springer
Purpose P-glycoprotein (Pgp) is an efflux protein found amongst other locations in the blood–
brain barrier. It is important to investigate the effect of Pgp modulation on clinically used …

Evaluation of three quinoline-carboxamide derivatives as potential radioligands for the in vivo pet imaging of neurodegeneration

S Belloli, RM Moresco, M Matarrese, G Biella… - Neurochemistry …, 2004 - Elsevier
The peripheral-type benzodiazepine receptors (PBRs) are only minimally expressed in
normal brain parenchyma, where they are primarily localized in glial cells. Their basal …