Amyloid load: a more sensitive biomarker for amyloid imaging
A Whittington, RN Gunn - Journal of Nuclear Medicine, 2019 - Soc Nuclear Med
Amyloid-β (Aβ) plays a key role in the pathogenesis of Alzheimer disease (AD) and can be
imaged in vivo using 18F-florbetapir PET. A composite SUV ratio (SUVr) is a commonly used …
imaged in vivo using 18F-florbetapir PET. A composite SUV ratio (SUVr) is a commonly used …
[HTML][HTML] Quantification of amyloid PET for future clinical use: a state-of-the-art review
Amyloid-β (Aβ) pathology is one of the earliest detectable brain changes in Alzheimer's
disease (AD) pathogenesis. The overall load and spatial distribution of brain Aβ can be …
disease (AD) pathogenesis. The overall load and spatial distribution of brain Aβ can be …
TauIQ: A canonical image based algorithm to quantify tau PET scans
A Whittington, RN Gunn… - Journal of Nuclear …, 2021 - Soc Nuclear Med
Recently, AmyloidIQ was introduced as a new canonical image-based algorithm to quantify
amyloid PET scans and demonstrated increased power over traditional SUV ratio (SUVR) …
amyloid PET scans and demonstrated increased power over traditional SUV ratio (SUVR) …
[HTML][HTML] Using PET with 18F-AV-45 (florbetapir) to quantify brain amyloid load in a clinical environment
Purpose Positron emission tomography (PET) imaging of brain amyloid load has been
suggested as a core biomarker for Alzheimer's disease (AD). The aim of this study was to …
suggested as a core biomarker for Alzheimer's disease (AD). The aim of this study was to …
Clinical use and utility of amyloid imaging
Currently, 3 amyloid PET tracers are approved and commercially available for clinical use.
They allow for the accurate in vivo detection of amyloid plaques, one hallmark of Alzheimer …
They allow for the accurate in vivo detection of amyloid plaques, one hallmark of Alzheimer …
Improved power for characterizing longitudinal amyloid-β PET changes and evaluating amyloid-modifying treatments with a cerebral white matter reference region
K Chen, A Roontiva, P Thiyyagura, W Lee… - Journal of Nuclear …, 2015 - Soc Nuclear Med
In this article, we describe an image analysis strategy with improved power for tracking
longitudinal amyloid-β (Aβ) PET changes and evaluating Aβ-modifying treatments. Methods …
longitudinal amyloid-β (Aβ) PET changes and evaluating Aβ-modifying treatments. Methods …
Determining amyloid-β positivity using 18F-AZD4694 PET imaging
Amyloid-β deposition into plaques is a pathologic hallmark of Alzheimer disease appearing
years before the onset of symptoms. Although cerebral amyloid-β deposition occurs on a …
years before the onset of symptoms. Although cerebral amyloid-β deposition occurs on a …
Reference region selection and the association between the rate of amyloid accumulation over time and the baseline amyloid burden
J Blautzik, M Brendel, J Sauerbeck, S Kotz… - European journal of …, 2017 - Springer
Relative quantitative analysis of amyloid plaque burden in Alzheimer's disease (AD) patients
can be reported as standardized uptake value ratio (SUVR) from positron emission …
can be reported as standardized uptake value ratio (SUVR) from positron emission …
Quantification of 18F-florbetapir PET: comparison of two analysis methods
C Hutton, J Declerck, MA Mintun… - European journal of …, 2015 - Springer
Purpose 18 F-Florbetapir positron emission tomography (PET) can be used to image
amyloid burden in the human brain. A previously developed research method has been …
amyloid burden in the human brain. A previously developed research method has been …
[HTML][HTML] Advances in brain amyloid imaging
N Krishnadas, VL Villemagne, V Doré… - Seminars in nuclear …, 2021 - Elsevier
Amyloid-β (Aβ) PET imaging has now been available for over 15 years. The ability to detect
Aβ in vivo has greatly improved the clinical and research landscape of Alzheimer's disease …
Aβ in vivo has greatly improved the clinical and research landscape of Alzheimer's disease …