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Radiolabeled (4-Fluoro-3-Iodobenzyl) Guanidine Improves Imaging and Targeted Radionuclide Therapy of Norepinephrine Transporter–Expressing Tumors

A Yamaguchi, H Hanaoka, T Higuchi… - Journal of Nuclear …, 2018 - Soc Nuclear Med
18F-or 131I-labeled (4-fluoro-3-iodobenzyl) guanidine (FIBG) has been a promising yet
unattainable derivative of radioiodine-labeled meta-iodobenzylguanidine (MIBG), because …
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PET Imaging of Norepinephrine Transporter–Expressing Tumors Using 76Br-meta-Bromobenzylguanidine

S Watanabe, H Hanaoka, JX Liang, Y Iida… - Journal of Nuclear …, 2010 - Soc Nuclear Med
Meta-iodobenzylguanidine (MIBG) labeled with 123I or 131I has been widely used for the
diagnosis and radiotherapy of norepinephrine transporter (NET)–expressing tumors …
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Synthesis and evaluation of 18F-labeled benzylguanidine analogs for targeting the human norepinephrine transporter

H Zhang, R Huang, NVK Pillarsetty, DLJ Thorek… - European journal of …, 2014 - Springer
Abstract Purpose Both 131 I-and 123 I-labeled meta-iodobenzylguanidine (MIBG) have
been widely used in the clinic for targeted imaging of the norepinephrine transporter (NET) …
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Synthesis and evaluation of 4-[18F] fluoropropoxy-3-iodobenzylguanidine ([18F] FPOIBG): A novel 18F-labeled analogue of MIBG

G Vaidyanathan, D McDougald, E Koumarianou… - Nuclear medicine and …, 2015 - Elsevier
Introduction Radioiodinated meta-iodobenzylguanidine (MIBG), a norepinephrine
transporter (NET) substrate, has been extensively used as an imaging agent to study the …
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Imaging the Norepinephrine Transporter in Neuroblastoma: A Comparison of [18F]-MFBG and 123I-MIBG

H Zhang, R Huang, NKV Cheung, H Guo… - Clinical Cancer …, 2014 - AACR
Purpose: The norepinephrine transporter (NET) is a critical regulator of catecholamine
uptake in normal physiology and is expressed in neuroendocrine tumors like …
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Norepinephrine transporter as a target for imaging and therapy

N Pandit-Taskar, S Modak - Journal of Nuclear Medicine, 2017 - Soc Nuclear Med
The norepinephrine transporter (NET) is essential for norepinephrine uptake at the synaptic
terminals and adrenal chromaffin cells. In neuroendocrine tumors, NET can be targeted for …
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Radioiodinated metaiodobenzylguanidine (MIBG): radiochemistry, biology, and pharmacology

S Vallabhajosula, A Nikolopoulou - Seminars in nuclear medicine, 2011 - Elsevier
As an analogue of adrenergic neurotransmitter norepinephrine (NE),
metaiodobenzylguanidine (MIBG) demonstrates high uptake both in normal sympathetically …
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Biodistribution and dosimetry of 18F-meta-fluorobenzylguanidine: a first-in-human PET/CT imaging study of patients with neuroendocrine malignancies

N Pandit-Taskar, P Zanzonico, KD Staton… - Journal of Nuclear …, 2018 - Soc Nuclear Med
123I-meta-iodobenzylguanidine (123I-MIBG) imaging is currently a mainstay in the
evaluation of many neuroendocrine tumors, especially neuroblastoma. 123I-MIBG imaging …
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Tumor Dosimetry Using [124I]m-iodobenzylguanidine MicroPET/CT for [131I]m-iodobenzylguanidine Treatment of Neuroblastoma in a Murine Xenograft Model

Y Seo, WC Gustafson, SF Dannoon, EA Nekritz… - Molecular imaging and …, 2012 - Springer
Abstract Purpose [124 I] m-iodobenzylguanidine (124 I-mIBG) provides a quantitative tool for
pretherapy tumor imaging and dosimetry when performed before [131 I] m …
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A Practical, Automated Synthesis of meta-[18F]Fluorobenzylguanidine for Clinical Use

B Hu, AL Va̅vere, KD Neumann… - ACS chemical …, 2015 - ACS Publications
Many neuroendocrine tumors, such as neuroblastoma (NB), arise from neural crest cells of
the sympathetic nervous system. This nerve-like phenotype has been exploited for functional …
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