Recent advances in targeting the urokinase plasminogen activator with nanotherapeutics
The aberrant proteolytic landscape of the tumor microenvironment is a key contributor of
cancer progression. Overexpression of urokinase plasminogen activator (uPA) and/or its …
cancer progression. Overexpression of urokinase plasminogen activator (uPA) and/or its …
Positron emission computed tomography targeting urokinase plasminogen activator receptor (uPAR) in cancer: a systematic review
R Camedda, V Frantellizzi, R Danieli… - Expert Review of …, 2024 - Taylor & Francis
Introduction To provide an overview of the available literature data on clinical applications of
positron emission tomography (PET) targeting the urokinase-type plasminogen activator …
positron emission tomography (PET) targeting the urokinase-type plasminogen activator …
[HTML][HTML] Potential of UPAR, Αvβ6 integrin, and tissue factor as targets for molecular imaging of oral squamous cell carcinoma: evaluation of nine targets in primary …
M Lawaetz, A Christensen, K Juhl, K Karnov… - International Journal of …, 2023 - mdpi.com
No clinically approved tumor-specific imaging agents for head and neck cancer are currently
available. The identification of biomarkers with a high and homogenous expression in tumor …
available. The identification of biomarkers with a high and homogenous expression in tumor …
[HTML][HTML] Side-by-side comparison of uPAR-targeting optical imaging antibodies and antibody fragments for fluorescence-guided surgery of solid tumors
VM Baart, L van Manen, SS Bhairosingh… - Molecular Imaging and …, 2021 - Springer
Purpose Radical resection is paramount for curative oncological surgery. Fluorescence-
guided surgery (FGS) aids in intraoperative identification of tumor-positive resection …
guided surgery (FGS) aids in intraoperative identification of tumor-positive resection …
[HTML][HTML] Targeted imaging of uPAR expression in vivo with cyclic AE105 variants
JM Leth, EA Newcombe, AL Grønnemose… - Scientific Reports, 2023 - nature.com
A comprehensive literature reports on the correlation between elevated levels of urokinase-
type plasminogen activator receptor (uPAR) and the severity of diseases with chronic …
type plasminogen activator receptor (uPAR) and the severity of diseases with chronic …
[HTML][HTML] Urokinase-Type Plasminogen Activator Receptor (uPAR) Expression and [64Cu]Cu-DOTA-AE105 uPAR-PET/CT in Patient-Derived Xenograft Models of Oral …
M Lawaetz, T Binderup, A Christensen, K Juhl… - Molecular Imaging and …, 2023 - Springer
Abstract Purpose [64Cu] Cu-DOTA-AE105 urokinase-type plasminogen activator receptor
(uPAR)-PET/CT is a novel and promising imaging modality for cancer visualization, although …
(uPAR)-PET/CT is a novel and promising imaging modality for cancer visualization, although …
[HTML][HTML] Diagnostic Value of Preoperative uPAR-PET/CT in Regional Lymph Node Staging of Oral and Oropharyngeal Squamous Cell Carcinoma: A Prospective …
M Lawaetz, A Christensen, K Juhl, G Lelkaitis… - Diagnostics, 2023 - mdpi.com
The detection of lymph node metastases is a major challenge in oral and oropharyngeal
squamous cell carcinoma (OSCC and OPSCC). 68Ga-NOTA-AE105 is a novel positron …
squamous cell carcinoma (OSCC and OPSCC). 68Ga-NOTA-AE105 is a novel positron …
[HTML][HTML] uPAR (PLAUR) Marks Two Intra-Tumoral Subtypes of Glioblastoma: Insights from Single-Cell RNA Sequencing
Y He, KBV Døssing, M Rossing, FO Bagger… - International Journal of …, 2024 - mdpi.com
Urokinase plasminogen activator receptor (uPAR) encoded by the PLAUR gene is known as
a clinical marker for cell invasiveness in glioblastoma multiforme (GBM). It is additionally …
a clinical marker for cell invasiveness in glioblastoma multiforme (GBM). It is additionally …
[HTML][HTML] Urokinase-type plasminogen activator receptor (uPAR) assessed by liquid biopsies and PET/CT for prognostication in head and neck cancer patients
LM Risør, T Binderup, MØ Fosbøl, KF Andersen… - Scientific Reports, 2022 - nature.com
Strong prognostic biomarkers are lacking regarding the stratification of treatment and
surveillance regimens in head and neck squamous cell carcinoma (HNSCC). The study …
surveillance regimens in head and neck squamous cell carcinoma (HNSCC). The study …
[HTML][HTML] Human antibody VH domains targeting uPAR as candidate therapeutics for cancers
The high expression of uPAR has been linked to tumor progression, invasion, and
metastasis in several types of cancer. Such overexpression of uPAR makes it a potential …
metastasis in several types of cancer. Such overexpression of uPAR makes it a potential …