[HTML][HTML] CXCR4-targeted theranostics in oncology

AK Buck, SE Serfling, T Lindner, H Hänscheid… - European Journal of …, 2022 - Springer
A growing body of literature reports on the upregulation of CXC motif chemokine receptor 4
(CXCR4) in a variety of cancer entities, rendering this receptor as suitable target for …

[HTML][HTML] Radionuclide imaging and therapy directed towards the tumor microenvironment: A multi-cancer approach for personalized medicine

CD van der Heide, SU Dalm - European Journal of Nuclear Medicine and …, 2022 - Springer
Targeted radionuclide theranostics is becoming more and more prominent in clinical
oncology. Currently, most nuclear medicine compounds researched for cancer theranostics …

CXC motif chemokine receptor 4–targeted radioligand therapy in patients with advanced T-cell lymphoma

AK Buck, GU Grigoleit, S Kraus, A Schirbel… - Journal of Nuclear …, 2023 - Soc Nuclear Med
CXC motif chemokine receptor 4 (CXCR4)–targeted radioligand therapy (RLT) has already
been applied to advanced blood cancers, such as multiple myeloma or diffuse large B-cell …

Theranostics in hematooncology

AK Buck, SE Serfling, S Kraus, S Samnick… - Journal of Nuclear …, 2023 - Soc Nuclear Med
In the early 2000s, major clinical trials provided evidence of a favorable outcome from
antibody-mediated radioimmunotherapy for hematologic neoplasms, which then led to Food …

A pilot study of 68Ga-PSMA11 and 68Ga-RM2 PET/MRI for evaluation of prostate cancer response to high-intensity focused ultrasound therapy

H Duan, P Ghanouni, B Daniel… - Journal of Nuclear …, 2023 - Soc Nuclear Med
Focal therapy for localized prostate cancer (PC) using high-intensity focused ultrasound
(HIFU) is gaining in popularity as it is noninvasive and associated with fewer side effects …

[HTML][HTML] Impact of CXCR4-directed PET/CT on staging and proposed oncologic management in patients with digestive system tumors

A Weich, SE Serfling, W Schlötelburg… - Clinical nuclear …, 2023 - journals.lww.com
Purpose To elucidate the influence of CXC motif chemokine receptor 4 (CXCR4)–directed
imaging on staging and proposed oncologic management in patients with digestive system …

Nuclear medicine application of pentixafor/pentixather targeting CXCR4 for imaging and therapy in related disease

Z Chen, Q Xue, S Yao - Mini Reviews in Medicinal Chemistry, 2023 - ingentaconnect.com
CXC-motif chemokine receptor 4 (CXCR4) is a novel predictive biomarker for metastasis
and poor prognosis in individuals with malignancies. CXCL12 is the only cognate ligand of …

[HTML][HTML] Lymphoma-sink effect in marginal zone lymphoma based on CXCR4-targeted molecular imaging

A Kosmala, S Seifert, S Schneid, N Dreher… - Molecular Imaging and …, 2023 - Springer
Purpose Recent studies investigating a tumor-sink effect in solid tumors reported on
decreasing uptake in normal organs in patients with higher tumor burden. This …

68Ga-Labeled Cystine Knot Peptide Targeting Integrin αvβ6 for Lung Cancer PET Imaging

J Ren, S Zhu, G Zhang, X Tan, L Qiu, J Lin… - Molecular …, 2022 - ACS Publications
Integrin αvβ6 has been considered as a promising biomarker for lung cancer, and its
expression is often related to poor prognosis. An αvβ6-binding cystine knot peptide R01-MG …

Synthesis, Screening, and Evaluation of Theranostic Molecular CPCR4-Based Probe Targeting CXCR4

T Yang, D Shi, Q Lin, H Shen, H Tan, Y Liu… - Molecular …, 2024 - ACS Publications
Chemokines and chemokine receptors are indispensable to play a key role in the
development of malignant tumors. As one of the most widely expressed chemokine …