[HTML][HTML] Molecular and functional imaging in cancer-targeted therapy: current applications and future directions

JW Bai, SQ Qiu, GJ Zhang - Signal Transduction and Targeted Therapy, 2023 - nature.com
Targeted anticancer drugs block cancer cell growth by interfering with specific signaling
pathways vital to carcinogenesis and tumor growth rather than harming all rapidly dividing …

[HTML][HTML] Protein scaffolds: antibody alternatives for cancer diagnosis and therapy

R Luo, H Liu, Z Cheng - RSC chemical biology, 2022 - pubs.rsc.org
Although antibodies are well developed and widely used in cancer therapy and diagnostic
fields, some defects remain, such as poor tissue penetration, long in vivo metabolic …

[HTML][HTML] Phase I Trial of [99mTc]Tc-maSSS-PEG2-RM26, a Bombesin Analogue Antagonistic to Gastrin-Releasing Peptide Receptors (GRPRs), for SPECT Imaging …

V Chernov, A Rybina, R Zelchan, A Medvedeva… - Cancers, 2023 - mdpi.com
Simple Summary Prostate and breast cancers are the most common malignancies. Accurate
diagnosis and staging of diseases are important for the prognosis and determination of …

[HTML][HTML] Direct Intra-Patient Comparison of Scaffold Protein-Based Tracers, [99mTc]Tc-ADAPT6 and [99mTc]Tc-(HE)3-G3, for Imaging of HER2-Positive Breast …

O Bragina, V Chernov, A Schulga, E Konovalova… - Cancers, 2023 - mdpi.com
Simple Summary The receptor HER2 is overexpressed in some breast cancers. Tumours
with a high HER2 expression can be successfully treated with the antibodies trastuzumab …

[HTML][HTML] Direct In Vivo Comparison of 99mTc-Labeled Scaffold Proteins, DARPin G3 and ADAPT6, for Visualization of HER2 Expression and Monitoring of Early …

V Tolmachev, V Bodenko, M Oroujeni, S Deyev… - International Journal of …, 2022 - mdpi.com
Non-invasive radionuclide molecular visualization of human epidermal growth factor
receptor type 2 (HER2) can provide stratification of patients for HER2-targeting therapy. This …

[HTML][HTML] Antibodies as Biosensors' Key Components: State-of-the-Art in Russia 2020–2021

N Rudenko, K Fursova, A Shepelyakovskaya… - Sensors, 2021 - mdpi.com
The recognition of biomolecules is crucial in key areas such as the timely diagnosis of
somatic and infectious diseases, food quality control, and environmental monitoring. This …

[HTML][HTML] The evolution of targeted radionuclide diagnosis of HER2-Positive breast cancer

OD Bragina, SM Deyev, VI Chernov, VM Tolmachev - Acta Naturae, 2022 - ncbi.nlm.nih.gov
This review examines the evolution of the radionuclide diagnosis of HER2-positive breast
cancer using various compounds as a targeting module in clinical practice: from full-length …

[HTML][HTML] Preclinical evaluation of EpCAM-binding designed ankyrin repeat proteins (DARPins) as targeting moieties for bimodal near-infrared fluorescence and …

RD Houvast, N Badr, T March, LDAN de Muynck… - European Journal of …, 2023 - Springer
Purpose Fluorescence-guided surgery (FGS) can play a key role in improving radical
resection rates by assisting surgeons to gain adequate visualization of malignant tissue …

[HTML][HTML] The production of the first functional antibody mimetic in higher plants: the chloroplast makes the DARPin G3 for HER2 imaging in oncology

M Ehsasatvatan, BB Kohnehrouz, A Gholizadeh… - Biological Research, 2022 - Springer
Background Designed mimetic molecules are attractive tools in biopharmaceuticals and
synthetic biology. They require mass and functional production for the assessment of …

[HTML][HTML] Comparative Preclinical Evaluation of Peptide-Based Chelators for the Labeling of DARPin G3 with 99mTc for Radionuclide Imaging of HER2 Expression in …

M Larkina, E Plotnikov, E Bezverkhniaia… - International Journal of …, 2022 - mdpi.com
Non-invasive radionuclide imaging of human epidermal growth factor receptor type 2
(HER2) expression in breast, gastroesophageal, and ovarian cancers may stratify patients …