Positron emission tomography (PET) uses radioactive tracers and enables the functional
imaging of several metabolic processes, blood flow measurements, regional chemical …

ABSTRACT α‐Synucleinopathies including idiopathic Parkinson's disease, dementia with
Lewy bodies and multiple systems atrophy share overlapping symptoms and pathological …

Transient soluble oligomers of amyloid-β (Aβ) are toxic and accumulate early prior to
insoluble plaque formation and cognitive impairment in Alzheimer's disease (AD). Synthetic …

Amyloid plaques composed of Aβ fibrils are a hallmark of Alzheimer's disease (AD).
However, the molecular architecture of amyloid plaques in the context of fresh mammalian …

Background Hijacking the transferrin receptor (TfR) is an effective strategy to transport
amyloid-beta (Aβ) immuno-positron emission tomography (immunoPET) ligands across the …

The use of transgenic mice displaying amyloid-β (Aβ) brain pathology has been essential for
the preclinical assessment of new treatment strategies for Alzheimer's disease. However, the …

Early detection and intervention for dementia represent tremendous unmet clinical needs
and priorities in society. A shared feature of neurodegenerative diseases causing dementia …

Background Brain-directed immunotherapy is a promising strategy to target amyloid-β (Aβ)
deposits in Alzheimer's disease (AD). In the present study, we compared the therapeutic …

Small molecule imaging agents such as [11C] PiB, which bind to the core of insoluble
amyloid-β (Aβ) fibrils, are useful tools in Alzheimer's disease (AD) research, diagnostics, and …

Animal models of Alzheimer's disease amyloidosis that recapitulate cerebral amyloid-beta
pathology have been widely used in preclinical research and have greatly enabled the …