[HTML][HTML] Predicting disruptions to drug pharmacokinetics and the risk of adverse drug reactions in non-alcoholic steatohepatitis patients
S Marie, KL Frost, RK Hau, L Martinez-Guerrero… - … Pharmaceutica Sinica B, 2023 - Elsevier
The liver plays a central role in the pharmacokinetics of drugs through drug metabolizing
enzymes and transporters. Non-alcoholic steatohepatitis (NASH) causes disease-specific …
enzymes and transporters. Non-alcoholic steatohepatitis (NASH) causes disease-specific …
Tc‐99m mebrofenin hepatobiliary scintigraphy to assess future liver remnant function before major liver surgery
H Smet, D Martin, E Uldry, R Duran… - Journal of Surgical …, 2023 - Wiley Online Library
Abstract Background and Objectives Assessment of liver function is paramount before
hepatectomy. This study aimed to assess future liver remnant function (FLR‐F) using …
hepatectomy. This study aimed to assess future liver remnant function (FLR‐F) using …
[HTML][HTML] Pharmacokinetic Imaging Using 99mTc-Mebrofenin to Untangle the Pattern of Hepatocyte Transporter Disruptions Induced by Endotoxemia in Rats
S Marie, I Hernández-Lozano, M Le Vée, L Breuil… - Pharmaceuticals, 2022 - mdpi.com
Endotoxemia-induced inflammation may impact the activity of hepatocyte transporters, which
control the hepatobiliary elimination of drugs and bile acids. 99mTc-mebrofenin is a non …
control the hepatobiliary elimination of drugs and bile acids. 99mTc-mebrofenin is a non …
[HTML][HTML] Imaging-Based Characterization of a Slco2b1(-/-) Mouse Model Using [11C]Erlotinib and [99mTc]Mebrofenin as Probe Substrates
S Marie, I Hernández-Lozano, L Breuil, C Truillet, S Hu… - Pharmaceutics, 2021 - mdpi.com
Organic anion-transporting polypeptide 2B1 (OATP2B1) is co-localized with OATP1B1 and
OATP1B3 in the basolateral hepatocyte membrane, where it is thought to contribute to the …
OATP1B3 in the basolateral hepatocyte membrane, where it is thought to contribute to the …