[HTML][HTML] Global experience with PSMA-based alpha therapy in prostate cancer

MM Sathekge, F Bruchertseifer, M Vorster… - European Journal of …, 2021 - Springer
Purpose This review discusses the current state of prostate-specific membrane antigen
(PSMA)-based alpha therapy of metastatic castration-resistant prostate cancer (mCRPC) …

[HTML][HTML] Prostate-specific membrane antigen biology in lethal prostate cancer and its therapeutic implications

B Sheehan, C Guo, A Neeb, A Paschalis… - European urology …, 2022 - Elsevier
Context Prostate-specific membrane antigen (PSMA) is a promising, novel theranostic target
in advanced prostate cancer (PCa). Multiple PSMA-targeted therapies are currently in …

[HTML][HTML] What a difference a methylene makes: replacing Glu with Asp or Aad in the Lys-urea-Glu pharmacophore of PSMA-targeting radioligands to reduce kidney …

HT Kuo, KS Lin, Z Zhang, C Zhang, H Merkens… - Theranostics, 2022 - ncbi.nlm.nih.gov
The aim of this study was to investigate the effect of replacing Glu in the Lys-urea-Glu PSMA-
targeting pharmacophore of [68 Ga] Ga-HTK03041 with a close analog on the uptake of …

Radiation dosimetry in 177Lu-PSMA-617 therapy

P Jackson, M Hofman, L McIntosh, JP Buteau… - Seminars in Nuclear …, 2022 - Elsevier
Radionuclide therapy using the small molecule PSMA bound to the beta-emitting
radionuclide, Lutetium-177 (177 Lu-PSMA) has demonstrated efficacy and survival benefit …

[PDF][PDF] The interplay between monosodium glutamate (MSG) consumption and metabolic disorders

OT Kayode, JA Bello, JA Oguntola, AAA Kayode… - Heliyon, 2023 - cell.com
Monosodium glutamate (MSG) is one of the most popular food additives in the world and is
often ingested with commercially processed foods. It can be described as a sodium salt of …

Monosodium glutamate safety, neurotoxicity and some recent studies

F Farhat - Al-Azhar Journal of Pharmaceutical Sciences, 2021 - journals.ekb.eg
Monosodium glutamate (MSG) is a worldwide flavor enhancer. Despite controversy
surrounding the safety of MSG, it is still consumed in large amounts. This review provides a …

[HTML][HTML] Characterization of Non-Specific Uptake and Retention Mechanisms of [177Lu]Lu-PSMA-617 in the Salivary Glands

N Heynickx, C Segers, A Coolkens, S Baatout… - Pharmaceuticals, 2023 - mdpi.com
The radionuclide therapy [177Lu] Lu-PSMA-617 was recently FDA-approved for treatment of
metastatic castration-resistant prostate cancer. Salivary gland toxicity is currently considered …

The Role of Monosodium Glutamate (MSG) in Epilepsy and other Neurodegenerative Diseases: Phytochemical-based Therapeutic Approa-ches and Mechanisms

M Singh, SP Panda - Current Pharmaceutical Biotechnology, 2024 - ingentaconnect.com
Epilepsy is a common neurological disease affecting 50 million individuals worldwide, and
some forms of epilepsy do not respond to available treatments. Overactivation of the …

[HTML][HTML] Competitive blocking of salivary gland [18F]DCFPyL uptake via localized, retrograde ductal injection of non-radioactive DCFPyL: a preclinical study

J Roy, BM Warner, F Basuli, X Zhang, C Zheng… - EJNMMI research, 2021 - Springer
Background PSMA-targeted radionuclide therapy (TRT) is a promising treatment for prostate
cancer (PCa), but dose-limiting xerostomia can severely limit its clinical adaptation …

[HTML][HTML] Predicting the effect of different folate doses on [68Ga]Ga-PSMA-11 organ and tumor uptake using physiologically based pharmacokinetic modeling

H Siebinga, JJMA Hendrikx, ADR Huitema… - EJNMMI research, 2023 - Springer
Background Folate intake might reduce [68Ga] Ga-PSMA-11 uptake in tissues due to a
competitive binding to the PSMA receptor. For diagnostic imaging, this could impact decision …