[PDF][PDF] Metabolic analysis as a driver for discovery, diagnosis, and therapy
RJ DeBerardinis, KR Keshari - Cell, 2022 - cell.com
Metabolic anomalies contribute to tissue dysfunction. Current metabolism research spans
from organelles to populations, and new technologies can accommodate investigation …
from organelles to populations, and new technologies can accommodate investigation …
[HTML][HTML] Novel applications of molecular imaging to guide breast cancer therapy
CE Edmonds, SR O'Brien, DA Mankoff, AR Pantel - Cancer Imaging, 2022 - Springer
The goals of precision oncology are to provide targeted drug therapy based on each
individual's specific tumor biology, and to enable the prediction and early assessment of …
individual's specific tumor biology, and to enable the prediction and early assessment of …
Hyperpolarized [5-13C,4,4-2H2,5-15N]-L-glutamine provides a means of annotating in vivo metabolic utilization of glutamine
R Eskandari, N Kim, A Mamakhanyan… - Proceedings of the …, 2022 - National Acad Sciences
Glutamine is consumed by rapidly proliferating cells and can provide the carbon and
nitrogen required for growth through various metabolic pathways. However, delineating the …
nitrogen required for growth through various metabolic pathways. However, delineating the …
Evaluation of (2S,4S)-4-[18F]FEBGln as a Positron Emission Tomography Tracer for Tumor Imaging
Y Huang, Y Liu, C Li, Z Li, H Chen, L Zhang… - Molecular …, 2023 - ACS Publications
Glutamine metabolism-related tracers have the potential to visualize numerous tumors
because glutamine is the second largest source of energy for tumors.(2S, 4S)-4-[18F] …
because glutamine is the second largest source of energy for tumors.(2S, 4S)-4-[18F] …
First-in-human PET imaging and estimated radiation dosimetry of L-[5-11C]-glutamine in patients with metastatic colorectal cancer
AS Cohen, J Grudzinski, GT Smith… - Journal of Nuclear …, 2022 - Soc Nuclear Med
Altered metabolism is a hallmark of cancer. In addition to glucose, glutamine is an important
nutrient for cellular growth and proliferation. Noninvasive imaging via PET may help facilitate …
nutrient for cellular growth and proliferation. Noninvasive imaging via PET may help facilitate …
18F-Fluciclovine PET Imaging of Glutaminase Inhibition in Breast Cancer Models
Aggressive cancers such as triple-negative breast cancer (TNBC) avidly metabolize
glutamine as a feature of their malignant phenotype. The conversion of glutamine to …
glutamine as a feature of their malignant phenotype. The conversion of glutamine to …
[HTML][HTML] [18F](2S, 4R)-4-Fluoroglutamine as a new positron emission tomography tracer in myeloma
The high glycolytic activity of multiple myeloma (MM) cells is the rationale for use of Positron
Emission Tomography (PET) with 18F-fluorodeoxyglucose ([18F] FDG) to detect both bone …
Emission Tomography (PET) with 18F-fluorodeoxyglucose ([18F] FDG) to detect both bone …
Kinetic and Static Analysis of Poly-(Adenosine Diphosphate-Ribose) Polymerase-1–Targeted 18F-Fluorthanatrace PET Images of Ovarian Cancer
AJ Young, AR Pantel, V Viswanath… - Journal of Nuclear …, 2022 - Soc Nuclear Med
The poly-(adenosine diphosphate-ribose) polymerase (PARP) family of proteins participates
in numerous functions, most notably the DNA damage response. Cancer vulnerability to …
in numerous functions, most notably the DNA damage response. Cancer vulnerability to …
[HTML][HTML] Comparison of: (2S,4R)-4-[18F]Fluoroglutamine, [11C]Methionine, and 2-Deoxy-2-[18F]Fluoro-D-Glucose and Two Small-Animal PET/CT Systems …
MWG Miner, H Liljenbäck, J Virta, S Helin… - Frontiers in …, 2021 - frontiersin.org
Purpose The three positron emission tomography (PET) imaging compounds:(2 S, 4 R)-4-
[18F] Fluoroglutamine ([18F] FGln), L-[methyl-11C] Methionine ([11C] Met), and 2-deoxy-2 …
[18F] Fluoroglutamine ([18F] FGln), L-[methyl-11C] Methionine ([11C] Met), and 2-deoxy-2 …
Analysis of four-dimensional data for total body pet imaging
In clinical practice, most PET imaging is performed at a single timepoint after tracer injection—
that is,“static” PET imaging. In practice, static [18F]-fluorodeoxyglucose (FDG) PET scans are …
that is,“static” PET imaging. In practice, static [18F]-fluorodeoxyglucose (FDG) PET scans are …