Imaging-guided targeted radionuclide tumor therapy: From concept to clinical translation

J Sun, Z Huangfu, J Yang, G Wang, K Hu, M Gao… - Advanced Drug Delivery …, 2022 - Elsevier
Since the first introduction of sodium iodide I-131 for use with thyroid patients almost 80
years ago, more than 50 radiopharmaceuticals have reached the markets for a wide range …

[HTML][HTML] Skin cancer pathobiology at a glance: a focus on imaging techniques and their potential for improved diagnosis and surveillance in clinical cohorts

EG Dobre, M Surcel, C Constantin, MA Ilie… - International Journal of …, 2023 - mdpi.com
Early diagnosis is essential for completely eradicating skin cancer and maximizing patients'
clinical benefits. Emerging optical imaging modalities such as reflectance confocal …

Toward Clinical Transfer of Tumor‐Targeted Ultrasmall Inorganic Nanoparticles

L Carmès, M Banerjee, P Coliat, S Harlepp… - Advanced …, 2023 - Wiley Online Library
Ultrasmall nanoparticles (USNs)(nanoparticles with hydrodynamic diameter< 10 nm) are
being widely developed pre‐clinically and started to emerge in clinical trials over the last …

[HTML][HTML] Optimizing the Safety and Efficacy of Bio-Radiopharmaceuticals for Cancer Therapy

CN Funeh, J Bridoux, T Ertveldt, TWM De Groof… - Pharmaceutics, 2023 - mdpi.com
The precise delivery of cytotoxic radiation to cancer cells through the combination of a
specific targeting vector with a radionuclide for targeted radionuclide therapy (TRT) has …

[HTML][HTML] Peptides for diagnosis and treatment of ovarian cancer

L Guo, J Wang, N Li, J Cui, Y Su - Frontiers in Oncology, 2023 - frontiersin.org
Ovarian cancer is the most deadly gynecologic malignancy, and its incidence is gradually
increasing. Despite improvements after treatment, the results are unsatisfactory and survival …

Combined probe strategy to increase the enzymatic digestion rate and accelerate the renal radioactivity clearance of peptide radiotracers

M Zhang, J Ye, Z Xie, Y Wang, W Ma… - Molecular …, 2022 - ACS Publications
High and sustained renal radioactivity accumulation is a major challenge in peptide-based
radionuclide imaging and therapy. However, neutral endopeptidase (NEP)-based enzymatic …

5‐Hydroxypyrroloindoline Affords Tryptathionine and 2, 2′‐bis‐Indole Peptide Staples: Application to Melanotan‐II

M Todorovic, A Blanc, Z Wang, J Lozada… - … A European Journal, 2024 - Wiley Online Library
With peptides increasingly favored as drugs, natural product motifs, namely the
tryptathionine staple, found in amatoxins and phallotoxins, and the 2, 2'‐bis‐indole found in …

MC1R and melanin-based molecular probes for theranostic of melanoma and beyond

H Shi, Z Cheng - Acta Pharmacologica Sinica, 2022 - nature.com
Malignant melanoma is accounting for most of skin cancer-associated mortality. The
incidence of melanoma increased every year worldwide especially in western countries …

[HTML][HTML] Pre-clinical evaluation of biomarkers for the early detection of nephrotoxicity following alpha-particle radioligand therapy

M Li, C Robles-Planells, D Liu, SA Graves… - European journal of …, 2023 - Springer
Purpose Cancer treatment with alpha-emitter-based radioligand therapies (α-RLTs)
demonstrates promising tumor responses. Radiolabeled peptides are filtered through …

Advances in the research and application of neurokinin-1 receptor antagonists

X Hong, J Ma, S Zheng, G Zhao, C Fu - Journal of Zhejiang University …, 2024 - Springer
Recently, the substance P (SP)/neurokinin-1 receptor (NK-1R) system has been found to be
involved in various human pathophysiological disorders including the symptoms of …