[HTML][HTML] ImmunoPET: antibody-based PET imaging in solid tumors

R Manafi-Farid, B Ataeinia, S Ranjbar… - Frontiers in …, 2022 - frontiersin.org
Immuno-positron emission tomography (immunoPET) is a molecular imaging modality
combining the high sensitivity of PET with the specific targeting ability of monoclonal …

Pretargeting: a path forward for radioimmunotherapy

SM Cheal, SK Chung, BA Vaughn… - Journal of Nuclear …, 2022 - Soc Nuclear Med
Pretargeted radioimmunodiagnosis and radioimmunotherapy aim to efficiently combine
antitumor antibodies and medicinal radioisotopes for high-contrast imaging and high …

[HTML][HTML] Immuno-PET: Design options and clinical proof-of-concept

A Lugat, C Bailly, M Chérel, C Rousseau… - Frontiers in …, 2022 - frontiersin.org
Radioimmunoconjugates have been used for over 30 years in nuclear medicine
applications. In the last few years, advances in cancer biology knowledge have led to the …

Current landscape in clinical pretargeted radioimmunoimaging and therapy

VIJ Jallinoja, JL Houghton - Journal of Nuclear Medicine, 2021 - Soc Nuclear Med
The principle of pretargeted radioimmunoimaging and therapy has been investigated over
the past 30 y in preclinical and clinical settings with the aim of reducing the radiation burden …

Immuno-PET of colorectal cancer with a CEA-targeted [68 Ga] Ga-nanobody: From bench to bedside

L Li, X Lin, L Wang, X Ma, Z Zeng, F Liu, B Jia… - European Journal of …, 2023 - Springer
Purpose An accurate diagnosis of colorectal carcinoma (CRC) can assist physicians in
developing reasonable therapeutic regimens, thereby significantly improving the patient's …

[HTML][HTML] Preclinical PET imaging of granzyme B shows promotion of immunological response following combination paclitaxel and immune checkpoint inhibition in …

TS Napier, CL Hunter, PN Song, BM Larimer… - Pharmaceutics, 2022 - mdpi.com
Advancements in monitoring and predicting of patient-specific response of triple negative
breast cancer (TNBC) to immunotherapy (IMT) with and without chemotherapy are needed …

Anti-CEA pretargeted immuno-PET shows higher sensitivity than DOPA PET/CT in detecting relapsing metastatic medullary thyroid carcinoma: post hoc analysis of the …

C Bodet-Milin, A Faivre-Chauvet, T Carlier… - Journal of Nuclear …, 2021 - Soc Nuclear Med
Pretargeting parameters for the use of anti–carcinoembryonic antigen (CEA) bispecific
monoclonal antibody TF2 and the 68Ga-labeled IMP288 peptide for immuno-PET have …

Promising clinical performance of pretargeted immuno-PET with anti-CEA bispecific antibody and gallium-68-labelled IMP-288 peptide for imaging colorectal cancer …

Y Touchefeu, C Bailly, E Frampas, T Eugène… - European Journal of …, 2021 - Springer
Introduction This pilot study evaluated the imaging performance of pretargeted
immunological positron emission tomography (immuno-PET) using an anti …

Generation and in vivo characterization of a novel high-affinity human antibody targeting carcinoembryonic antigen

L Plüss, F Peissert, A Elsayed, G Rotta, J Römer… - MAbs, 2023 - Taylor & Francis
There are no effective treatment options for most patients with metastatic colorectal cancer
(mCRC). mCRC remains a leading cause of tumor-related death, with a five-year survival …

Cucurbituril–Ferrocene: Host–Guest Based Pretargeted Positron Emission Tomography in a Xenograft Model

VIJ Jallinoja, BD Carney, M Zhu, K Bhatt… - Bioconjugate …, 2021 - ACS Publications
Pretargeted positron emission tomography is a macromolecule-driven nuclear medicine
technique that involves targeting a preadministered antigen target-bound macromolecule …